8 Citations (Scopus)

Abstract

Motor-skill learning induces changes in synaptic structure and function in the primary motor cortex through the involvement of a long-term potentiation- (LTP-) like mechanism. Although there is evidence that calcium-dependent release of gliotransmitters by astrocytes plays an important role in synaptic transmission and plasticity, the role of astrocytes in motor-skill learning is not known. To test the hypothesis that astrocytic activity is necessary for motor-skill learning, we perturbed astrocytic function using pharmacological and genetic approaches. We find that perturbation of astrocytes either by selectively attenuating IP3R2 mediated astrocyte Ca2+ signaling or using an astrocyte specific metabolic inhibitor fluorocitrate (FC) results in impaired motor-skill learning of a forelimb reaching-task in mice. Moreover, the learning impairment caused by blocking astrocytic activity using FC was rescued by administration of the gliotransmitter D-serine. The learning impairments are likely caused by impaired LTP as FC blocked LTP in slices and prevented motor-skill training-induced increases in synaptic AMPA-type glutamate receptor in vivo. These results support the conclusion that normal astrocytic Ca2+ signaling during a reaching task is necessary for motor-skill learning.

Original languageEnglish (US)
Article number938023
JournalNeural Plasticity
Volume2015
DOIs
StatePublished - Jan 1 2015

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Motor Skills
Learning
Astrocytes
Neuronal Plasticity
AMPA Receptors
Forelimb
Long-Term Potentiation
Glutamate Receptors
Motor Cortex
Synaptic Transmission
Serine
Pharmacology
Calcium
fluorocitrate

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Motor-skill learning is dependent on astrocytic activity. / Padmashri, Ragunathan; Suresh, Anand; Boska, Michael D; Dunaevsky-Hutt, Anna.

In: Neural Plasticity, Vol. 2015, 938023, 01.01.2015.

Research output: Contribution to journalArticle

Padmashri, Ragunathan ; Suresh, Anand ; Boska, Michael D ; Dunaevsky-Hutt, Anna. / Motor-skill learning is dependent on astrocytic activity. In: Neural Plasticity. 2015 ; Vol. 2015.
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