Motor and premotor cortices in subcortical stroke: Proton magnetic resonance spectroscopy measures and arm motor impairment

Sorin C. Craciunas, William M. Brooks, Randolph J. Nudo, Elena A. Popescu, In Young Choi, Phil Lee, Hung Wen Yeh, Cary R. Savage, Carmen M. Cirstea

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background. Although functional imaging and neurophysiological approaches reveal alterations in motor and premotor areas after stroke, insights into neurobiological events underlying these alterations are limited in human studies. Objective. We tested whether cerebral metabolites related to neuronal and glial compartments are altered in the hand representation in bilateral motor and premotor areas and correlated with distal and proximal arm motor impairment in hemiparetic persons. Methods. In 20 participants at >6 months postonset of a subcortical ischemic stroke and 16 age- and sex-matched healthy controls, the concentrations of N-acetylaspartate and myo-inositol were quantified by proton magnetic resonance spectroscopy. Regions of interest identified by functional magnetic resonance imaging included primary (M1), dorsal premotor (PMd), and supplementary (SMA) motor areas. Relationships between metabolite concentrations and distal (hand) and proximal (shoulder/elbow) motor impairment using Fugl-Meyer Upper Extremity (FMUE) subscores were explored. Results. N-Acetylaspartate was lower in M1 (P =.04) and SMA (P =.004) and myo-inositol was higher in M1 (P =.003) and PMd (P =.03) in the injured (ipsilesional) hemisphere after stroke compared with the left hemisphere in controls. N-Acetylaspartate in ipsilesional M1 was positively correlated with hand FMUE subscores (P =.04). Significant positive correlations were also found between N-acetylaspartate in ipsilesional M1, PMd, and SMA and in contralesional M1 and shoulder/elbow FMUE subscores (P =.02,.01,.02, and.02, respectively). Conclusions. Our preliminary results demonstrated that proton magnetic resonance spectroscopy is a sensitive method to quantify relevant neuronal changes in spared motor cortex after stroke and consequently increase our knowledge of the factors leading from these changes to arm motor impairment.

Original languageEnglish (US)
Pages (from-to)411-420
Number of pages10
JournalNeurorehabilitation and Neural Repair
Volume27
Issue number5
DOIs
StatePublished - Jun 1 2013

Fingerprint

Motor Cortex
Arm
Stroke
Upper Extremity
Hand
Inositol
Elbow
Neuroglia
Proton Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
N-acetylaspartate

Keywords

  • distal and proximal arm motor impairment
  • motor and premotor cortices
  • proton magnetic resonance spectroscopy
  • subcortical stroke

ASJC Scopus subject areas

  • Rehabilitation
  • Neurology
  • Clinical Neurology

Cite this

Motor and premotor cortices in subcortical stroke : Proton magnetic resonance spectroscopy measures and arm motor impairment. / Craciunas, Sorin C.; Brooks, William M.; Nudo, Randolph J.; Popescu, Elena A.; Choi, In Young; Lee, Phil; Yeh, Hung Wen; Savage, Cary R.; Cirstea, Carmen M.

In: Neurorehabilitation and Neural Repair, Vol. 27, No. 5, 01.06.2013, p. 411-420.

Research output: Contribution to journalArticle

Craciunas, Sorin C. ; Brooks, William M. ; Nudo, Randolph J. ; Popescu, Elena A. ; Choi, In Young ; Lee, Phil ; Yeh, Hung Wen ; Savage, Cary R. ; Cirstea, Carmen M. / Motor and premotor cortices in subcortical stroke : Proton magnetic resonance spectroscopy measures and arm motor impairment. In: Neurorehabilitation and Neural Repair. 2013 ; Vol. 27, No. 5. pp. 411-420.
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AU - Nudo, Randolph J.

AU - Popescu, Elena A.

AU - Choi, In Young

AU - Lee, Phil

AU - Yeh, Hung Wen

AU - Savage, Cary R.

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