Motor and absorptive function of the canine intestine following serosal patching: The effects of a lateral enterotomy on small intestinal myoelectrical activity

Jon S Thompson, E. M M Quigley

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We studied the effects of serosal patching of a 4 × 15-cm, full-thickness, jejunal defect on absorptive function and fasting and postprandial myoelectrical activity in 5 patched and 5 control animals over a 3-month period. While fat and D-xylose absorption were similar in both groups, serum albumin was significantly depressed (2.96 ± 0.24 g/dL preop vs 2.29 ± 0.23 g/dL postop, p > 05) andstool moisture content was elevated following patching (54 ± 4% vs 67 ± 9% p > 05). Neither the generation of the various phases of the interdigestive myoelectrical complex (IDMEC), the development of postprandial myoelectrical activity, or colonic myoelectrical patterns were impaired in the patched animals. The normal gradients of slow wave frequency, phase III propagation velocity, and onset of the fed pattern were similar in control and patched animals. However, jejunal slow wave frequency (cpm, control vs patch: 18.6 ± 0.6 vs 19.5 ± 0.6, p > 05) and IDMEC frequency (0.36 ± 0.25 vs 0.56 ± 0.32, p > 05) were greater and the IDMEC period shorter (109.6 ± 27.8 vs 88 ± 35.7, p > 05) in the patch animals. In vitro studies demonstrated similar absorptive function in intact mucosa and neomucosa. We conclude that the technique of serosal patching is associated with impaired absorption in vivo. While this may be related, in part, to the minor motility changes observed, other factors such as hormonal changes may also be important

Original languageEnglish (US)
Pages (from-to)203-215
Number of pages13
JournalJournal of Investigative Surgery
Volume4
Issue number2
DOIs
StatePublished - Jan 1 1991

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Intestines
Canidae
Xylose
Serum Albumin
Fasting
Mucous Membrane
Fats

Keywords

  • Intestinal absorption
  • Intestinal motility
  • Serosal patch
  • Short bowel syndrome

ASJC Scopus subject areas

  • Surgery

Cite this

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title = "Motor and absorptive function of the canine intestine following serosal patching: The effects of a lateral enterotomy on small intestinal myoelectrical activity",
abstract = "We studied the effects of serosal patching of a 4 × 15-cm, full-thickness, jejunal defect on absorptive function and fasting and postprandial myoelectrical activity in 5 patched and 5 control animals over a 3-month period. While fat and D-xylose absorption were similar in both groups, serum albumin was significantly depressed (2.96 ± 0.24 g/dL preop vs 2.29 ± 0.23 g/dL postop, p > 05) andstool moisture content was elevated following patching (54 ± 4{\%} vs 67 ± 9{\%} p > 05). Neither the generation of the various phases of the interdigestive myoelectrical complex (IDMEC), the development of postprandial myoelectrical activity, or colonic myoelectrical patterns were impaired in the patched animals. The normal gradients of slow wave frequency, phase III propagation velocity, and onset of the fed pattern were similar in control and patched animals. However, jejunal slow wave frequency (cpm, control vs patch: 18.6 ± 0.6 vs 19.5 ± 0.6, p > 05) and IDMEC frequency (0.36 ± 0.25 vs 0.56 ± 0.32, p > 05) were greater and the IDMEC period shorter (109.6 ± 27.8 vs 88 ± 35.7, p > 05) in the patch animals. In vitro studies demonstrated similar absorptive function in intact mucosa and neomucosa. We conclude that the technique of serosal patching is associated with impaired absorption in vivo. While this may be related, in part, to the minor motility changes observed, other factors such as hormonal changes may also be important",
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