Morphology and development in Aspergillus nidulans: a complex puzzle.

Steven D. Harris, Geoffrey Turner, Vera Meyer, Eduardo A. Espeso, Thomas Specht, Norio Takeshita, Kerstin Helmstedt

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Like other filamentous fungi, Aspergillus nidulans forms a multitude of cell types that facilitate colonization and development. The molecular basis of cellular morphogenesis in A. nidulans is not well understood.Here, we summarize results obtained from detailed annotation of the A. nidulans genome sequence for genes with predicted roles in morphogenesis, with primary focus on polarized growth, calcium signaling, and development. We draw three broad conclusions from our results. First, the components of the signal transduction pathways and morphogenetic machinery as defined in the model yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe are largely conserved in A. nidulans. Second,A. nidulans possesses many additional genes implicated in morphogenesis that are not conserved in these yeasts. Third, the number of A. nidulans genes involved in morphogenesis is likely to be rather large;based on our annotation, we estimate that as many as 2000 A. nidulans genes encode proteins that may participate at some level in morphogenesis during vegetative growth and development.

Original languageEnglish (US)
Pages (from-to)S82-S92
JournalFungal genetics and biology : FG & B
Volume46 Suppl 1
DOIs
StatePublished - Mar 2009

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Aspergillus nidulans
Morphogenesis
Yeasts
Genes
Calcium Signaling
Schizosaccharomyces
Growth and Development
Saccharomyces cerevisiae
Signal Transduction
Fungi
Genome
Growth

ASJC Scopus subject areas

  • Microbiology
  • Genetics

Cite this

Harris, S. D., Turner, G., Meyer, V., Espeso, E. A., Specht, T., Takeshita, N., & Helmstedt, K. (2009). Morphology and development in Aspergillus nidulans: a complex puzzle. Fungal genetics and biology : FG & B, 46 Suppl 1, S82-S92. https://doi.org/10.1016/j.fgb.2008.07.023

Morphology and development in Aspergillus nidulans : a complex puzzle. / Harris, Steven D.; Turner, Geoffrey; Meyer, Vera; Espeso, Eduardo A.; Specht, Thomas; Takeshita, Norio; Helmstedt, Kerstin.

In: Fungal genetics and biology : FG & B, Vol. 46 Suppl 1, 03.2009, p. S82-S92.

Research output: Contribution to journalArticle

Harris, SD, Turner, G, Meyer, V, Espeso, EA, Specht, T, Takeshita, N & Helmstedt, K 2009, 'Morphology and development in Aspergillus nidulans: a complex puzzle.', Fungal genetics and biology : FG & B, vol. 46 Suppl 1, pp. S82-S92. https://doi.org/10.1016/j.fgb.2008.07.023
Harris SD, Turner G, Meyer V, Espeso EA, Specht T, Takeshita N et al. Morphology and development in Aspergillus nidulans: a complex puzzle. Fungal genetics and biology : FG & B. 2009 Mar;46 Suppl 1:S82-S92. https://doi.org/10.1016/j.fgb.2008.07.023
Harris, Steven D. ; Turner, Geoffrey ; Meyer, Vera ; Espeso, Eduardo A. ; Specht, Thomas ; Takeshita, Norio ; Helmstedt, Kerstin. / Morphology and development in Aspergillus nidulans : a complex puzzle. In: Fungal genetics and biology : FG & B. 2009 ; Vol. 46 Suppl 1. pp. S82-S92.
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