Abstract
A shunt connecting the descending aorta and posterior vena cava was established surgically in six mongrel dogs. All animals subsequently developed hemodynamic and clinical signs of congestive heart failure at which time the shunt was closed. Six to seven weeks after ligation of the shunt, activity of the left atrial stretch receptors was recorded and found to be similar to that of sham-operated dogs. Methylene blue-stained sections of left atrial endocardium indicated that approximately one-third of the receptors were normal in histological appearance. The remaining two-thirds were fragmented and degenerate. Evidence is presented which indicates that structural changes in these receptors parallel their changes in physiological activity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 510-514 |
| Number of pages | 5 |
| Journal | Basic Research in Cardiology |
| Volume | 75 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 1 1980 |
Fingerprint
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine
- Physiology (medical)
Cite this
Morphological changes accompanying physiological changes in atrial stretch receptors. / Earle, A. M.; Zucker, Irving H; Earle, A. C.; Gilmore, J. P.
In: Basic Research in Cardiology, Vol. 75, No. 4, 01.07.1980, p. 510-514.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Morphological changes accompanying physiological changes in atrial stretch receptors
AU - Earle, A. M.
AU - Zucker, Irving H
AU - Earle, A. C.
AU - Gilmore, J. P.
PY - 1980/7/1
Y1 - 1980/7/1
N2 - A shunt connecting the descending aorta and posterior vena cava was established surgically in six mongrel dogs. All animals subsequently developed hemodynamic and clinical signs of congestive heart failure at which time the shunt was closed. Six to seven weeks after ligation of the shunt, activity of the left atrial stretch receptors was recorded and found to be similar to that of sham-operated dogs. Methylene blue-stained sections of left atrial endocardium indicated that approximately one-third of the receptors were normal in histological appearance. The remaining two-thirds were fragmented and degenerate. Evidence is presented which indicates that structural changes in these receptors parallel their changes in physiological activity.
AB - A shunt connecting the descending aorta and posterior vena cava was established surgically in six mongrel dogs. All animals subsequently developed hemodynamic and clinical signs of congestive heart failure at which time the shunt was closed. Six to seven weeks after ligation of the shunt, activity of the left atrial stretch receptors was recorded and found to be similar to that of sham-operated dogs. Methylene blue-stained sections of left atrial endocardium indicated that approximately one-third of the receptors were normal in histological appearance. The remaining two-thirds were fragmented and degenerate. Evidence is presented which indicates that structural changes in these receptors parallel their changes in physiological activity.
UR - http://www.scopus.com/inward/record.url?scp=0018854124&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018854124&partnerID=8YFLogxK
U2 - 10.1007/BF01907832
DO - 10.1007/BF01907832
M3 - Article
VL - 75
SP - 510
EP - 514
JO - Basic Research in Cardiology
JF - Basic Research in Cardiology
SN - 0300-8428
IS - 4
ER -