Morphologic and Biochemical Changes in Dogs After Portacaval Shunt Plus Bile Fistula or Ileal Bypass

Failure of Bile Fistula or Ileal Bypass to Prevent Hepatocyte Atrophy

Jon S Thompson, K. A. Porter, N. Hayashida, D. J. McNamara, T. S. Parker, W. J. Russell, A. Francavilla, T. E. Starzl

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

External biliary fistula (BF) or ileal bypass (IB) was performed in dogs at the time of or 2 weeks after portacaval shunt (PCS). The pathologic changes in the dog livers 2 to 4 weeks later were compared to those caused by PCS alone. Histopathologic differences between PCS alone vs. PCS plus BF or IB could not be found. Thus, the experiments did not confirm recent observations by others in rats that BF prevents or reverses the hepatic injury of PCS. As estimated by plasma mevalonic acid determinations, the increase in hepatic cholesterol synthesis that is characteristic after BF or IB was suppressed in animals with PCS. BF and IB reduced but did not eliminate the postprandial elevation in serum bile acid that occurs after PCS. The findings have possible relevance in planning the treatment of patients with familial hypercholesterolemia with the combined use of PCS and IB.

Original languageEnglish (US)
Pages (from-to)581-587
Number of pages7
JournalHepatology
Volume3
Issue number4
DOIs
StatePublished - Jan 1 1983

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Surgical Portacaval Shunt
Bile
Fistula
Atrophy
Biliary Fistula
Hepatocytes
Dogs
Liver
Cutaneous Fistula
Mevalonic Acid
Hyperlipoproteinemia Type II
Bile Acids and Salts
Cholesterol
Wounds and Injuries

ASJC Scopus subject areas

  • Hepatology

Cite this

Morphologic and Biochemical Changes in Dogs After Portacaval Shunt Plus Bile Fistula or Ileal Bypass : Failure of Bile Fistula or Ileal Bypass to Prevent Hepatocyte Atrophy. / Thompson, Jon S; Porter, K. A.; Hayashida, N.; McNamara, D. J.; Parker, T. S.; Russell, W. J.; Francavilla, A.; Starzl, T. E.

In: Hepatology, Vol. 3, No. 4, 01.01.1983, p. 581-587.

Research output: Contribution to journalArticle

Thompson, Jon S ; Porter, K. A. ; Hayashida, N. ; McNamara, D. J. ; Parker, T. S. ; Russell, W. J. ; Francavilla, A. ; Starzl, T. E. / Morphologic and Biochemical Changes in Dogs After Portacaval Shunt Plus Bile Fistula or Ileal Bypass : Failure of Bile Fistula or Ileal Bypass to Prevent Hepatocyte Atrophy. In: Hepatology. 1983 ; Vol. 3, No. 4. pp. 581-587.
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abstract = "External biliary fistula (BF) or ileal bypass (IB) was performed in dogs at the time of or 2 weeks after portacaval shunt (PCS). The pathologic changes in the dog livers 2 to 4 weeks later were compared to those caused by PCS alone. Histopathologic differences between PCS alone vs. PCS plus BF or IB could not be found. Thus, the experiments did not confirm recent observations by others in rats that BF prevents or reverses the hepatic injury of PCS. As estimated by plasma mevalonic acid determinations, the increase in hepatic cholesterol synthesis that is characteristic after BF or IB was suppressed in animals with PCS. BF and IB reduced but did not eliminate the postprandial elevation in serum bile acid that occurs after PCS. The findings have possible relevance in planning the treatment of patients with familial hypercholesterolemia with the combined use of PCS and IB.",
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