Mononuclear phagocyte immunity and the neuropathogenesis of HIV-1 infection

Yuri Persidsky, Howard Eliot Gendelman

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

Human immunodeficiency virus type 1 (HIV-1)-associated dementia is a neuroinflammatory brain disorder that is fueled by viral infection and immune activation of brain mononuclear phagocytes (MP; macrophages and microglia). MP serve as a reservoir for persistent viral infection, a vehicle for viral dissemination throughout the brain, and a major source of neurotoxic products that when produced in abundance, affect neuronal function. Such neurotoxic substances secreted by MP lead to clinical neurological impairment (cognitive, behavior, and motor abnormalities), which occurs usually years after the initial viral infection. How HIV-1 evades the immune function characteristic for MP as a first line of defense, including phagocytosis and intracellular killing, is not well understood despite more than two decades of study. In this report, we review the complex role(s) played by MP in the neuropathogenesis of HIV-1 infection. The clinical manifestations, pathology and pathogenesis, and treatment options are discussed in relationship to innate and adaptive immunity. Particular emphasis is given to the diversity of MP functions and how it may affect the disease process and manifestations. New insights into disease mechanisms are provided by advances in enhanced magnetic resonance imaging and proteomics to identify cell movement and genetic profiles of disease. New therapeutic strategies are discussed based on current knowledge of HIV-1-associated dementia pathogenesis.

Original languageEnglish (US)
Pages (from-to)691-701
Number of pages11
JournalJournal of Leukocyte Biology
Volume74
Issue number5
DOIs
StatePublished - Nov 1 2003

Fingerprint

Virus Diseases
Phagocytes
HIV-1
Immunity
Dementia
Inborn Genetic Diseases
Clinical Pathology
Brain
Microglia
Brain Diseases
Adaptive Immunity
Phagocytosis
Innate Immunity
Proteomics
Cell Movement
Macrophages
Magnetic Resonance Imaging
Therapeutics

Keywords

  • Animal model
  • Blood-brain barrier
  • HIV-1 encephalitis
  • Neuronal damage

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

Cite this

Mononuclear phagocyte immunity and the neuropathogenesis of HIV-1 infection. / Persidsky, Yuri; Gendelman, Howard Eliot.

In: Journal of Leukocyte Biology, Vol. 74, No. 5, 01.11.2003, p. 691-701.

Research output: Contribution to journalArticle

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