Monoamine oxidase inhibitors. Synthesis of a series of isopropylidine and isopropyl derivatives of some aryl and arylalkyl acid hydrazides

M. H. Weinswig, Edward B Roche

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Six isopropylidene hydrazides and six isopropyl hydrazides were prepared. This investigation was undertaken since recent derivatives of hydrazines and hydrazides have shown considerable activity as monoamine oxidase inhibitors. The hydrazides were synthesized from the aryl and arylalkylesters and hydrazine. From these hydrazides the isopropylidene derivatives were prepared by refluxing with acetone. Reduction of the isopropylidene hydrazides, using hydrogen and 5 per cent platinum‐on‐charcoal catalyst, gave the isopropyl hydrazides. The hydrazides prepared were of benzoic acid, phenylacetic acid, α‐naphthoic acid, β‐naphthoic acid, α‐naphthylacetic acid, and β‐naphthylacetic acid.

Original languageEnglish (US)
Pages (from-to)1216-1218
Number of pages3
JournalJournal of Pharmaceutical Sciences
Volume54
Issue number8
DOIs
StatePublished - Jan 1 1965

Fingerprint

Monoamine Oxidase Inhibitors
hydrazine
Acids
Hydrazines
Benzoic Acid
Acetone
Hydrogen
propylene
1-naphthoic acid

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Monoamine oxidase inhibitors. Synthesis of a series of isopropylidine and isopropyl derivatives of some aryl and arylalkyl acid hydrazides. / Weinswig, M. H.; Roche, Edward B.

In: Journal of Pharmaceutical Sciences, Vol. 54, No. 8, 01.01.1965, p. 1216-1218.

Research output: Contribution to journalArticle

@article{9f577d59dfc146fd91fbf2feabdf7405,
title = "Monoamine oxidase inhibitors. Synthesis of a series of isopropylidine and isopropyl derivatives of some aryl and arylalkyl acid hydrazides",
abstract = "Six isopropylidene hydrazides and six isopropyl hydrazides were prepared. This investigation was undertaken since recent derivatives of hydrazines and hydrazides have shown considerable activity as monoamine oxidase inhibitors. The hydrazides were synthesized from the aryl and arylalkylesters and hydrazine. From these hydrazides the isopropylidene derivatives were prepared by refluxing with acetone. Reduction of the isopropylidene hydrazides, using hydrogen and 5 per cent platinum‐on‐charcoal catalyst, gave the isopropyl hydrazides. The hydrazides prepared were of benzoic acid, phenylacetic acid, α‐naphthoic acid, β‐naphthoic acid, α‐naphthylacetic acid, and β‐naphthylacetic acid.",
author = "Weinswig, {M. H.} and Roche, {Edward B}",
year = "1965",
month = "1",
day = "1",
doi = "10.1002/jps.2600540831",
language = "English (US)",
volume = "54",
pages = "1216--1218",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "John Wiley and Sons Inc.",
number = "8",

}

TY - JOUR

T1 - Monoamine oxidase inhibitors. Synthesis of a series of isopropylidine and isopropyl derivatives of some aryl and arylalkyl acid hydrazides

AU - Weinswig, M. H.

AU - Roche, Edward B

PY - 1965/1/1

Y1 - 1965/1/1

N2 - Six isopropylidene hydrazides and six isopropyl hydrazides were prepared. This investigation was undertaken since recent derivatives of hydrazines and hydrazides have shown considerable activity as monoamine oxidase inhibitors. The hydrazides were synthesized from the aryl and arylalkylesters and hydrazine. From these hydrazides the isopropylidene derivatives were prepared by refluxing with acetone. Reduction of the isopropylidene hydrazides, using hydrogen and 5 per cent platinum‐on‐charcoal catalyst, gave the isopropyl hydrazides. The hydrazides prepared were of benzoic acid, phenylacetic acid, α‐naphthoic acid, β‐naphthoic acid, α‐naphthylacetic acid, and β‐naphthylacetic acid.

AB - Six isopropylidene hydrazides and six isopropyl hydrazides were prepared. This investigation was undertaken since recent derivatives of hydrazines and hydrazides have shown considerable activity as monoamine oxidase inhibitors. The hydrazides were synthesized from the aryl and arylalkylesters and hydrazine. From these hydrazides the isopropylidene derivatives were prepared by refluxing with acetone. Reduction of the isopropylidene hydrazides, using hydrogen and 5 per cent platinum‐on‐charcoal catalyst, gave the isopropyl hydrazides. The hydrazides prepared were of benzoic acid, phenylacetic acid, α‐naphthoic acid, β‐naphthoic acid, α‐naphthylacetic acid, and β‐naphthylacetic acid.

UR - http://www.scopus.com/inward/record.url?scp=0013795162&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0013795162&partnerID=8YFLogxK

U2 - 10.1002/jps.2600540831

DO - 10.1002/jps.2600540831

M3 - Article

VL - 54

SP - 1216

EP - 1218

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 8

ER -