Monitoring of smokeless tobacco consumers using cytogenetic endpoints

A. H. Trivedi, B. J. Dave, S. G. Adhvaryu

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Smokeless tobacco consumption is causally associated with oral cavity cancers; however extensive cytogenetic studies have not been done. In the present study individuals consuming dry snuff or tobacco with lime have been studied for frequency of micronucleated cells (MNC) in exfoliated buccal mucosa and chromosome aberrations (CA) and sister chromatid exchanges (SCE) in lymphocytes. The significant elevation in the values of all the three cytogenetic markers among tobacco users compared to the controls reveal the extent of genomic damage on target and nontarget tissues. The findings emphasize the possible use of cytogenetic endpoints for monitoring smokeless tobacco consumers.

Original languageEnglish (US)
Pages (from-to)2245-2249
Number of pages5
JournalAnticancer Research
Volume13
Issue number6 A
StatePublished - Dec 1 1993

Fingerprint

Smokeless Tobacco
Cytogenetics
Tobacco
Sister Chromatid Exchange
Mouth Neoplasms
Mouth Mucosa
Tobacco Use
Chromosome Aberrations
Mouth
Lymphocytes

Keywords

  • Buccal mucosa cells
  • Cancer of oral cavity
  • Chromosome aberration
  • Human lymphocytes
  • Micronucleus
  • Sister chromatid exchange
  • Snuff
  • Tobacco plus lime chewing

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Monitoring of smokeless tobacco consumers using cytogenetic endpoints. / Trivedi, A. H.; Dave, B. J.; Adhvaryu, S. G.

In: Anticancer Research, Vol. 13, No. 6 A, 01.12.1993, p. 2245-2249.

Research output: Contribution to journalArticle

Trivedi, AH, Dave, BJ & Adhvaryu, SG 1993, 'Monitoring of smokeless tobacco consumers using cytogenetic endpoints', Anticancer Research, vol. 13, no. 6 A, pp. 2245-2249.
Trivedi, A. H. ; Dave, B. J. ; Adhvaryu, S. G. / Monitoring of smokeless tobacco consumers using cytogenetic endpoints. In: Anticancer Research. 1993 ; Vol. 13, No. 6 A. pp. 2245-2249.
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