The intestinal multiplicity in mice heterozygous for Apc(Min) is strongly modulated by genetic background. On the sensitive C57BL/6J (B6) background, mice develop large numbers of intestinal adenomas. The AKR/J (AKR) strain carries alleles that correlate with a strong reduction in tumor multiplicity. To study the effect of one of these modifiers, Mom1, we have generated a mouse line in which the AKR allele of Mom1 is carried on the sensitive B6 genetic background. This strain was produced by using a marker- assisted selection method to eliminate unlinked AKR alleles more rapidly. The application and efficacy of this are discussed. We used this strain to determine that Mom1 affects both tumor multiplicity and tumor size in a semi- domain fashion.
|Original language||English (US)|
|Number of pages||8|
|State||Published - Dec 1 1996|
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