Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice

Karen A. Gould, William F. Dietrich, Natalie Borenstein, Eric S. Lander, William F. Dove

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Abstract

The intestinal multiplicity in mice heterozygous for Apc(Min) is strongly modulated by genetic background. On the sensitive C57BL/6J (B6) background, mice develop large numbers of intestinal adenomas. The AKR/J (AKR) strain carries alleles that correlate with a strong reduction in tumor multiplicity. To study the effect of one of these modifiers, Mom1, we have generated a mouse line in which the AKR allele of Mom1 is carried on the sensitive B6 genetic background. This strain was produced by using a marker- assisted selection method to eliminate unlinked AKR alleles more rapidly. The application and efficacy of this are discussed. We used this strain to determine that Mom1 affects both tumor multiplicity and tumor size in a semi- domain fashion.

Original languageEnglish (US)
Pages (from-to)1769-1776
Number of pages8
JournalGenetics
Volume144
Issue number4
StatePublished - Dec 1 1996

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ASJC Scopus subject areas

  • Genetics

Cite this

Gould, K. A., Dietrich, W. F., Borenstein, N., Lander, E. S., & Dove, W. F. (1996). Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice. Genetics, 144(4), 1769-1776.