Molecular targets of antihypertensive peptides: Understanding the mechanisms of action based on the pathophysiology of hypertension

Kaustav Majumder, Jianping Wu

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

There is growing interest in using functional foods or nutraceuticals for the prevention and treatment of hypertension or high blood pressure. Although numerous preventive and therapeutic pharmacological interventions are available on the market, unfortunately, many patients still suffer from poorly controlled hypertension. Furthermore, most pharmacological drugs, such as inhibitors of angiotensin-I converting enzyme (ACE), are often associated with significant adverse effects. Many bioactive food compounds have been characterized over the past decades that may contribute to the management of hypertension; for example, bioactive peptides derived from various food proteins with antihypertensive properties have gained a great deal of attention. Some of these peptides have exhibited potent in vivo antihypertensive activity in both animal models and human clinical trials. This review provides an overview about the complex pathophysiology of hypertension and demonstrates the potential roles of food derived bioactive peptides as viable interventions targeting specific pathways involved in this disease process. This review offers a comprehensive guide for understanding and utilizing the molecular mechanisms of antihypertensive actions of food protein derived peptides.

Original languageEnglish (US)
Pages (from-to)256-283
Number of pages28
JournalInternational journal of molecular sciences
Volume16
Issue number1
DOIs
StatePublished - Dec 24 2014

Fingerprint

hypertension
food
Antihypertensive Agents
Peptides
peptides
Hypertension
activity (biology)
Food
Proteins
angiotensins
Pharmacology
Blood pressure
proteins
blood pressure
Functional Food
Angiotensin-Converting Enzyme Inhibitors
animal models
Dietary Supplements
Animals
Enzymes

Keywords

  • Angiotensin converting enzyme
  • Antihypertensive peptides
  • Endothelin
  • Hypertension
  • Nitric oxide
  • Spontaneously hypertensive rats

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

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abstract = "There is growing interest in using functional foods or nutraceuticals for the prevention and treatment of hypertension or high blood pressure. Although numerous preventive and therapeutic pharmacological interventions are available on the market, unfortunately, many patients still suffer from poorly controlled hypertension. Furthermore, most pharmacological drugs, such as inhibitors of angiotensin-I converting enzyme (ACE), are often associated with significant adverse effects. Many bioactive food compounds have been characterized over the past decades that may contribute to the management of hypertension; for example, bioactive peptides derived from various food proteins with antihypertensive properties have gained a great deal of attention. Some of these peptides have exhibited potent in vivo antihypertensive activity in both animal models and human clinical trials. This review provides an overview about the complex pathophysiology of hypertension and demonstrates the potential roles of food derived bioactive peptides as viable interventions targeting specific pathways involved in this disease process. This review offers a comprehensive guide for understanding and utilizing the molecular mechanisms of antihypertensive actions of food protein derived peptides.",
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