Molecular signaling and translational significance of the corticotropin releasing factor system

Patrick J. Ronan, Cliff H. Summers

Research output: Chapter in Book/Report/Conference proceedingChapter

18 Scopus citations

Abstract

The corticotropin releasing factor (CRF) system coordinates a wide range of stress responses and has been implicated in the etiology of a number of clinical disorders. It is made up of a complex array of interactive peptides that interact with many other neurotransmitter and neuromodulatory systems. Dysregulation of CRF system signaling may be a common molecular pathway for the myriad "stress-related" disorders. Understanding the signaling and circuitry affected by this system is essential to understanding these psychiatric disorders. The extremely wide range of behaviors and physiological processes mediated by this system and the complexity of its signaling make this a difficult taskespecially to successfully target it for pharmacotherapy. In this review, we describe the molecular signaling of the CRF system and its interaction with other key neurotransmitter systems. Its role in a range of psychiatric disorders and potential as a target for therapeutic intervention will also be discussed.

Original languageEnglish (US)
Title of host publicationProgress in Molecular Biology and Translational Science
PublisherElsevier B.V.
Pages235-292
Number of pages58
EditionC
DOIs
StatePublished - 2011

Publication series

NameProgress in Molecular Biology and Translational Science
NumberC
Volume98
ISSN (Print)1877-1173

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ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Cite this

Ronan, P. J., & Summers, C. H. (2011). Molecular signaling and translational significance of the corticotropin releasing factor system. In Progress in Molecular Biology and Translational Science (C ed., pp. 235-292). (Progress in Molecular Biology and Translational Science; Vol. 98, No. C). Elsevier B.V.. https://doi.org/10.1016/B978-0-12-385506-0.00006-5