Abstract
We study molecular recognition of two closely resembling posttranslational modification products, phosphotyrosine (pTyr) and sulfotyrosine (sTyr). The differences in charge, size, and binding geometry of pTyr and sTyr are the main recognition elements. Protein engineering can be applied to alter the specificity and strength of the recognition.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1829-1832 |
| Number of pages | 4 |
| Journal | Molecular BioSystems |
| Volume | 9 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jan 1 2013 |
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ASJC Scopus subject areas
- Biotechnology
- Molecular Biology
- Medicine(all)
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Molecular recognition of sulfotyrosine and phosphotyrosine by the Src homology 2 domain. / Ju, Tong; Niu, Wei; Cerny, Ronald; Bollman, Joshua; Roy, Anthony; Guo, Jiantao.
In: Molecular BioSystems, Vol. 9, No. 7, 01.01.2013, p. 1829-1832.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Molecular recognition of sulfotyrosine and phosphotyrosine by the Src homology 2 domain
AU - Ju, Tong
AU - Niu, Wei
AU - Cerny, Ronald
AU - Bollman, Joshua
AU - Roy, Anthony
AU - Guo, Jiantao
PY - 2013/1/1
Y1 - 2013/1/1
N2 - We study molecular recognition of two closely resembling posttranslational modification products, phosphotyrosine (pTyr) and sulfotyrosine (sTyr). The differences in charge, size, and binding geometry of pTyr and sTyr are the main recognition elements. Protein engineering can be applied to alter the specificity and strength of the recognition.
AB - We study molecular recognition of two closely resembling posttranslational modification products, phosphotyrosine (pTyr) and sulfotyrosine (sTyr). The differences in charge, size, and binding geometry of pTyr and sTyr are the main recognition elements. Protein engineering can be applied to alter the specificity and strength of the recognition.
UR - http://www.scopus.com/inward/record.url?scp=84878712129&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878712129&partnerID=8YFLogxK
U2 - 10.1039/c3mb70061e
DO - 10.1039/c3mb70061e
M3 - Article
VL - 9
SP - 1829
EP - 1832
JO - Molecular BioSystems
JF - Molecular BioSystems
SN - 1742-206X
IS - 7
ER -