Molecular recognition of sulfotyrosine and phosphotyrosine by the Src homology 2 domain

Tong Ju, Wei Niu, Ronald Cerny, Joshua Bollman, Anthony Roy, Jiantao Guo

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We study molecular recognition of two closely resembling posttranslational modification products, phosphotyrosine (pTyr) and sulfotyrosine (sTyr). The differences in charge, size, and binding geometry of pTyr and sTyr are the main recognition elements. Protein engineering can be applied to alter the specificity and strength of the recognition.

Original languageEnglish (US)
Pages (from-to)1829-1832
Number of pages4
JournalMolecular BioSystems
Volume9
Issue number7
DOIs
StatePublished - Jan 1 2013

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Phosphotyrosine
src Homology Domains
Protein Engineering
Post Translational Protein Processing
tyrosine O-sulfate

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Medicine(all)

Cite this

Molecular recognition of sulfotyrosine and phosphotyrosine by the Src homology 2 domain. / Ju, Tong; Niu, Wei; Cerny, Ronald; Bollman, Joshua; Roy, Anthony; Guo, Jiantao.

In: Molecular BioSystems, Vol. 9, No. 7, 01.01.2013, p. 1829-1832.

Research output: Contribution to journalArticle

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