Molecular recognition of sulfotyrosine and phosphotyrosine by the Src homology 2 domain

Tong Ju; Wei Niu; Ronald Cerny; Joshua Bollman; Anthony Roy; Jiantao Guo

doi:10.1039/c3mb70061e

Molecular recognition of sulfotyrosine and phosphotyrosine by the Src homology 2 domain

Tong Ju, Wei Niu, Ronald Cerny, Joshua Bollman, Anthony Roy, Jiantao Guo

Research output: Contribution to journal › Article

9 Scopus citations

Abstract

We study molecular recognition of two closely resembling posttranslational modification products, phosphotyrosine (pTyr) and sulfotyrosine (sTyr). The differences in charge, size, and binding geometry of pTyr and sTyr are the main recognition elements. Protein engineering can be applied to alter the specificity and strength of the recognition.

Original language	English (US)
Pages (from-to)	1829-1832
Number of pages	4
Journal	Molecular BioSystems
Volume	9
Issue number	7
DOIs	https://doi.org/10.1039/c3mb70061e
Publication status	Published - Jul 2013

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ASJC Scopus subject areas

Biotechnology
Molecular Biology

Cite this

Ju, T., Niu, W., Cerny, R., Bollman, J., Roy, A., & Guo, J. (2013). Molecular recognition of sulfotyrosine and phosphotyrosine by the Src homology 2 domain. Molecular BioSystems, 9(7), 1829-1832. https://doi.org/10.1039/c3mb70061e

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Access to Document

10.1039/c3mb70061e