Molecular recognition of sulfotyrosine and phosphotyrosine by the Src homology 2 domain

Tong Ju, Wei Niu, Ronald Cerny, Joshua Bollman, Anthony Roy, Jiantao Guo

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

We study molecular recognition of two closely resembling posttranslational modification products, phosphotyrosine (pTyr) and sulfotyrosine (sTyr). The differences in charge, size, and binding geometry of pTyr and sTyr are the main recognition elements. Protein engineering can be applied to alter the specificity and strength of the recognition.

Original languageEnglish (US)
Pages (from-to)1829-1832
Number of pages4
JournalMolecular BioSystems
Volume9
Issue number7
DOIs
Publication statusPublished - Jul 2013

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ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology

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