MOlecular Pathology Of Early Pancreatic Cancer

Neeley Remmers, Jennifer M. Bailey, Ashley M. Mohr, Michael A Hollingsworth

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

We describe the pathology of early pancreatic cancer and present an overview of known molecular alterations that occur in these lesions. There are three defined precursor lesions in current models of pancreatic cancer: pancreatic intraepithelial neoplasia (PanIN), mucinous cystic neoplasms (MCN), and intraductal papillary mucinous neoplasms (IPMN). Molecular alterations detected in these lesions include: telomeres, K-ras and downstream targets, p16/CDKN2A, p53, SMAD4/DPC4, microRNAs, mucins and their post-translational processing, inflammatory cytokines, CEACAM, and epigenetic alterations. We summarize previous analyses of these markers as diagnostic markers of disease, and suggest areas of future study.

Original languageEnglish (US)
Title of host publicationTranslational Pathology of Early Cancer
PublisherIOS Press
Pages421-440
Number of pages20
ISBN (Print)9781614990239
DOIs
StatePublished - Mar 1 2012

Fingerprint

Molecular Pathology
Mucins
Pathology
MicroRNAs
Pancreatic Neoplasms
Cytokines
Processing
Neoplasms
Telomere
Epigenomics

Keywords

  • CA19-9
  • CEACAM
  • Intraductal papillary mucinous neoplasms (IPMN)
  • K-ras
  • MIC1
  • Microrna
  • Mucin
  • Mucinous cystic neoplasms (MCN)
  • P16/CDKN2A
  • P53
  • Pancreatic cancer
  • Pancreatic intraepithelial neoplasia (PanIN)
  • SMAD4/DPC4

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Remmers, N., Bailey, J. M., Mohr, A. M., & Hollingsworth, M. A. (2012). MOlecular Pathology Of Early Pancreatic Cancer. In Translational Pathology of Early Cancer (pp. 421-440). IOS Press. https://doi.org/10.3233/978-1-61499-024-6-421

MOlecular Pathology Of Early Pancreatic Cancer. / Remmers, Neeley; Bailey, Jennifer M.; Mohr, Ashley M.; Hollingsworth, Michael A.

Translational Pathology of Early Cancer. IOS Press, 2012. p. 421-440.

Research output: Chapter in Book/Report/Conference proceedingChapter

Remmers, N, Bailey, JM, Mohr, AM & Hollingsworth, MA 2012, MOlecular Pathology Of Early Pancreatic Cancer. in Translational Pathology of Early Cancer. IOS Press, pp. 421-440. https://doi.org/10.3233/978-1-61499-024-6-421
Remmers N, Bailey JM, Mohr AM, Hollingsworth MA. MOlecular Pathology Of Early Pancreatic Cancer. In Translational Pathology of Early Cancer. IOS Press. 2012. p. 421-440 https://doi.org/10.3233/978-1-61499-024-6-421
Remmers, Neeley ; Bailey, Jennifer M. ; Mohr, Ashley M. ; Hollingsworth, Michael A. / MOlecular Pathology Of Early Pancreatic Cancer. Translational Pathology of Early Cancer. IOS Press, 2012. pp. 421-440
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