Abstract
We describe the pathology of early pancreatic cancer and present an overview of known molecular alterations that occur in these lesions. There are three defined precursor lesions in current models of pancreatic cancer: pancreatic intraepithelial neoplasia (PanIN), mucinous cystic neoplasms (MCN), and intraductal papillary mucinous neoplasms (IPMN). Molecular alterations detected in these lesions include: telomeres, K-ras and downstream targets, p16/CDKN2A, p53, SMAD4/DPC4, microRNAs, mucins and their post-translational processing, inflammatory cytokines, CEACAM, and epigenetic alterations. We summarize previous analyses of these markers as diagnostic markers of disease, and suggest areas of future study.
| Original language | English (US) |
|---|---|
| Title of host publication | Translational Pathology of Early Cancer |
| Publisher | IOS Press |
| Pages | 421-440 |
| Number of pages | 20 |
| ISBN (Print) | 9781614990239 |
| DOIs | |
| State | Published - Mar 1 2012 |
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Keywords
- CA19-9
- CEACAM
- Intraductal papillary mucinous neoplasms (IPMN)
- K-ras
- MIC1
- Microrna
- Mucin
- Mucinous cystic neoplasms (MCN)
- P16/CDKN2A
- P53
- Pancreatic cancer
- Pancreatic intraepithelial neoplasia (PanIN)
- SMAD4/DPC4
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
MOlecular Pathology Of Early Pancreatic Cancer. / Remmers, Neeley; Bailey, Jennifer M.; Mohr, Ashley M.; Hollingsworth, Michael A.
Translational Pathology of Early Cancer. IOS Press, 2012. p. 421-440.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - MOlecular Pathology Of Early Pancreatic Cancer
AU - Remmers, Neeley
AU - Bailey, Jennifer M.
AU - Mohr, Ashley M.
AU - Hollingsworth, Michael A
PY - 2012/3/1
Y1 - 2012/3/1
N2 - We describe the pathology of early pancreatic cancer and present an overview of known molecular alterations that occur in these lesions. There are three defined precursor lesions in current models of pancreatic cancer: pancreatic intraepithelial neoplasia (PanIN), mucinous cystic neoplasms (MCN), and intraductal papillary mucinous neoplasms (IPMN). Molecular alterations detected in these lesions include: telomeres, K-ras and downstream targets, p16/CDKN2A, p53, SMAD4/DPC4, microRNAs, mucins and their post-translational processing, inflammatory cytokines, CEACAM, and epigenetic alterations. We summarize previous analyses of these markers as diagnostic markers of disease, and suggest areas of future study.
AB - We describe the pathology of early pancreatic cancer and present an overview of known molecular alterations that occur in these lesions. There are three defined precursor lesions in current models of pancreatic cancer: pancreatic intraepithelial neoplasia (PanIN), mucinous cystic neoplasms (MCN), and intraductal papillary mucinous neoplasms (IPMN). Molecular alterations detected in these lesions include: telomeres, K-ras and downstream targets, p16/CDKN2A, p53, SMAD4/DPC4, microRNAs, mucins and their post-translational processing, inflammatory cytokines, CEACAM, and epigenetic alterations. We summarize previous analyses of these markers as diagnostic markers of disease, and suggest areas of future study.
KW - CA19-9
KW - CEACAM
KW - Intraductal papillary mucinous neoplasms (IPMN)
KW - K-ras
KW - MIC1
KW - Microrna
KW - Mucin
KW - Mucinous cystic neoplasms (MCN)
KW - P16/CDKN2A
KW - P53
KW - Pancreatic cancer
KW - Pancreatic intraepithelial neoplasia (PanIN)
KW - SMAD4/DPC4
UR - http://www.scopus.com/inward/record.url?scp=84880189121&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880189121&partnerID=8YFLogxK
U2 - 10.3233/978-1-61499-024-6-421
DO - 10.3233/978-1-61499-024-6-421
M3 - Chapter
AN - SCOPUS:84880189121
SN - 9781614990239
SP - 421
EP - 440
BT - Translational Pathology of Early Cancer
PB - IOS Press
ER -