Molecular investigation of a multisource outbreak of Crimean-Congo hemorrhagic fever in the United Arab Emirates

Luis L. Rodriguez, Gary O. Maupin, Thomas G. Ksiazek, Pierre E. Rollin, Ali S Khan, Tino F. Schwarz, Richard S. Lofts, Jonathan F. Smith, Abdul M. Noor, Clarence J. Peters, Stuart T. Nichol

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

During the investigation of an outbreak of Crimean-Congo hemorrhagic fever (CCHF) in the United Arab Emirates (UAE) between 1994 and 1995, blood samples from suspected CCHF cases and ticks collected from livestock were tested for CCHF virus by antigen-capture ELISA and by a reverse transcription-polymerase chain reaction. Phylogenetic analysis of partial small (S) segment nucleotide sequences from four ticks and five human samples showed that with one exception, all the human and tick viruses clustered along with samples from Pakistan and Madagascar in one distinct lineage. Within this lineage, sequences from the UAE patients were identical or closely related to those from three Hyalomma spp. ticks obtained from livestock recently imported from Somalia. Another sequence from a UAE patient was more closely related to a CCHF virus from Nigeria. These data indicate that the 1994-1995 CCHF epidemic in the UAE was a multisource outbreak possibly associated with importation of CCHF virus-infected livestock and ticks.

Original languageEnglish (US)
Pages (from-to)512-518
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume57
Issue number5
DOIs
StatePublished - Jan 1 1997

Fingerprint

Crimean Hemorrhagic Fever
United Arab Emirates
Congo
Ticks
Crimean-Congo hemorrhagic fever virus
Disease Outbreaks
Livestock
Somalia
Madagascar
Pakistan
Nigeria
Reverse Transcription
Enzyme-Linked Immunosorbent Assay
Viruses
Antigens
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Molecular investigation of a multisource outbreak of Crimean-Congo hemorrhagic fever in the United Arab Emirates. / Rodriguez, Luis L.; Maupin, Gary O.; Ksiazek, Thomas G.; Rollin, Pierre E.; Khan, Ali S; Schwarz, Tino F.; Lofts, Richard S.; Smith, Jonathan F.; Noor, Abdul M.; Peters, Clarence J.; Nichol, Stuart T.

In: American Journal of Tropical Medicine and Hygiene, Vol. 57, No. 5, 01.01.1997, p. 512-518.

Research output: Contribution to journalArticle

Rodriguez, LL, Maupin, GO, Ksiazek, TG, Rollin, PE, Khan, AS, Schwarz, TF, Lofts, RS, Smith, JF, Noor, AM, Peters, CJ & Nichol, ST 1997, 'Molecular investigation of a multisource outbreak of Crimean-Congo hemorrhagic fever in the United Arab Emirates', American Journal of Tropical Medicine and Hygiene, vol. 57, no. 5, pp. 512-518. https://doi.org/10.4269/ajtmh.1997.57.512
Rodriguez, Luis L. ; Maupin, Gary O. ; Ksiazek, Thomas G. ; Rollin, Pierre E. ; Khan, Ali S ; Schwarz, Tino F. ; Lofts, Richard S. ; Smith, Jonathan F. ; Noor, Abdul M. ; Peters, Clarence J. ; Nichol, Stuart T. / Molecular investigation of a multisource outbreak of Crimean-Congo hemorrhagic fever in the United Arab Emirates. In: American Journal of Tropical Medicine and Hygiene. 1997 ; Vol. 57, No. 5. pp. 512-518.
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