Molecular Insights Into Pathogenesis of Peripheral T Cell Lymphoma: a Review

Waseem Lone, Aisha Alkhiniji, Jayadev Manikkam Umakanthan, Javeed Iqbal

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Purpose of Review: Peripheral T cell lymphoma (PTCL) is a heterogeneous group of lymphoproliferative neoplasms, with at least 29 distinct entities described in current WHO classification. Using present diagnostic approaches, more than a third of PTCL cases cannot be classified, hence designated as PTCL-not otherwise specified (PTCL-NOS). Herein, we summarize the current genomic findings and their role in the molecular pathogenesis in different PTCL entities. Recent Findings: Gene expression profiling (GEP) studies have identified distinct molecular signatures for accurate diagnosis and elucidated oncogenic pathways enriched in major PTCL entities. Furthermore, genomic characterization has identified recurrent somatic mutations and potential therapeutic targets. Further efforts are underway to develop genetically faithful murine models. Summary: GEP studies have identified molecular subgroups of PTCL, characterized by distinct genetic and epigenetic alterations. Understanding the molecular mechanisms of T cell lymphomagenesis using in vivo model will help to reveal novel therapeutic targets.

Original languageEnglish (US)
Pages (from-to)318-328
Number of pages11
JournalCurrent Hematologic Malignancy Reports
Volume13
Issue number4
DOIs
StatePublished - Aug 1 2018

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Keywords

  • Anaplastic large cell lymphoma
  • Angioimmunoblastic T cell lymphoma
  • Gene expression profiling
  • Molecular signature
  • PTCL
  • Peripheral T cell lymphoma-not otherwise specified

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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