Molecular imaging of influenza and other emerging respiratory viral infections

Mike Bray, James Lawler, Jason Paragas, Peter B. Jahrling, Daniel J. Mollura

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Research on the pathogenesis and therapy of influenza and other emerging respiratory viral infections would be aided by methods that directly visualize pathophysiologic processes in patients and laboratory animals. At present, imaging of diseases, such as swine-origin H1N1 influenza, is largely restricted to chest radiograph and computed tomography (CT), which can detect pulmonary structural changes in severely ill patients but are more limited in characterizing the early stages of illness, differentiating inflammation from infection or tracking immune responses. In contrast, imaging modalities, such as positron emission tomography, single photon emission CT, magnetic resonance imaging, and bioluminescence imaging, which have become useful tools for investigating the pathogenesis of a range of disease processes, could be used to advance in vivo studies of respiratory viral infections in patients and animals. Molecular techniques might also be used to identify novel biomarkers of disease progression and to evaluate new therapies.

Original languageEnglish (US)
Pages (from-to)1348-1359
Number of pages12
JournalJournal of Infectious Diseases
Volume203
Issue number10
DOIs
StatePublished - May 15 2011

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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