Molecular evidence of sexual transmission of ebola virus

S. E. Mate, J. R. Kugelman, T. G. Nyenswah, J. T. Ladner, M. R. Wiley, T. Cordier-Lassalle, A. Christie, G. P. Schroth, S. M. Gross, G. J. Davies-Wayne, S. A. Shinde, R. Murugan, S. B. Sieh, M. Badio, L. Fakoli, F. Taweh, E. De Wit, N. Van Doremalen, V. J. Munster, J. PettittK. Prieto, B. W. Humrighouse, U. Ströher, J. W. DiClaro, L. E. Hensley, R. J. Schoepp, D. Safronetz, J. Fair, J. H. Kuhn, D. J. Blackley, A. S. Laney, D. E. Williams, T. Lo, A. Gasasira, S. T. Nichol, P. Formenty, F. N. Kateh, K. M. DeCock, F. Bolay, M. Sanchez-Lockhart, G. Palacios

Research output: Contribution to journalArticle

211 Citations (Scopus)

Abstract

A suspected case of sexual transmission from a male survivor of Ebola virus disease (EVD) to his female partner (the patient in this report) occurred in Liberia in March 2015. Ebola virus (EBOV) genomes assembled from blood samples from the patient and a semen sample from the survivor were consistent with direct transmission. The genomes shared three substitutions that were absent from all other Western African EBOV sequences and that were distinct from the last documented transmission chain in Liberia before this case. Combined with epidemiologic data, the genomic analysis provides evidence of sexual transmission of EBOV and evidence of the persistence of infective EBOV in semen for 179 days or more after the onset of EVD.

Original languageEnglish (US)
Pages (from-to)2448-2454
Number of pages7
JournalNew England Journal of Medicine
Volume373
Issue number25
DOIs
StatePublished - Dec 17 2015

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Ebolavirus
Ebola Hemorrhagic Fever
Liberia
Semen
Survivors
Genome

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mate, S. E., Kugelman, J. R., Nyenswah, T. G., Ladner, J. T., Wiley, M. R., Cordier-Lassalle, T., ... Palacios, G. (2015). Molecular evidence of sexual transmission of ebola virus. New England Journal of Medicine, 373(25), 2448-2454. https://doi.org/10.1056/NEJMoa1509773

Molecular evidence of sexual transmission of ebola virus. / Mate, S. E.; Kugelman, J. R.; Nyenswah, T. G.; Ladner, J. T.; Wiley, M. R.; Cordier-Lassalle, T.; Christie, A.; Schroth, G. P.; Gross, S. M.; Davies-Wayne, G. J.; Shinde, S. A.; Murugan, R.; Sieh, S. B.; Badio, M.; Fakoli, L.; Taweh, F.; De Wit, E.; Van Doremalen, N.; Munster, V. J.; Pettitt, J.; Prieto, K.; Humrighouse, B. W.; Ströher, U.; DiClaro, J. W.; Hensley, L. E.; Schoepp, R. J.; Safronetz, D.; Fair, J.; Kuhn, J. H.; Blackley, D. J.; Laney, A. S.; Williams, D. E.; Lo, T.; Gasasira, A.; Nichol, S. T.; Formenty, P.; Kateh, F. N.; DeCock, K. M.; Bolay, F.; Sanchez-Lockhart, M.; Palacios, G.

In: New England Journal of Medicine, Vol. 373, No. 25, 17.12.2015, p. 2448-2454.

Research output: Contribution to journalArticle

Mate, SE, Kugelman, JR, Nyenswah, TG, Ladner, JT, Wiley, MR, Cordier-Lassalle, T, Christie, A, Schroth, GP, Gross, SM, Davies-Wayne, GJ, Shinde, SA, Murugan, R, Sieh, SB, Badio, M, Fakoli, L, Taweh, F, De Wit, E, Van Doremalen, N, Munster, VJ, Pettitt, J, Prieto, K, Humrighouse, BW, Ströher, U, DiClaro, JW, Hensley, LE, Schoepp, RJ, Safronetz, D, Fair, J, Kuhn, JH, Blackley, DJ, Laney, AS, Williams, DE, Lo, T, Gasasira, A, Nichol, ST, Formenty, P, Kateh, FN, DeCock, KM, Bolay, F, Sanchez-Lockhart, M & Palacios, G 2015, 'Molecular evidence of sexual transmission of ebola virus', New England Journal of Medicine, vol. 373, no. 25, pp. 2448-2454. https://doi.org/10.1056/NEJMoa1509773
Mate SE, Kugelman JR, Nyenswah TG, Ladner JT, Wiley MR, Cordier-Lassalle T et al. Molecular evidence of sexual transmission of ebola virus. New England Journal of Medicine. 2015 Dec 17;373(25):2448-2454. https://doi.org/10.1056/NEJMoa1509773
Mate, S. E. ; Kugelman, J. R. ; Nyenswah, T. G. ; Ladner, J. T. ; Wiley, M. R. ; Cordier-Lassalle, T. ; Christie, A. ; Schroth, G. P. ; Gross, S. M. ; Davies-Wayne, G. J. ; Shinde, S. A. ; Murugan, R. ; Sieh, S. B. ; Badio, M. ; Fakoli, L. ; Taweh, F. ; De Wit, E. ; Van Doremalen, N. ; Munster, V. J. ; Pettitt, J. ; Prieto, K. ; Humrighouse, B. W. ; Ströher, U. ; DiClaro, J. W. ; Hensley, L. E. ; Schoepp, R. J. ; Safronetz, D. ; Fair, J. ; Kuhn, J. H. ; Blackley, D. J. ; Laney, A. S. ; Williams, D. E. ; Lo, T. ; Gasasira, A. ; Nichol, S. T. ; Formenty, P. ; Kateh, F. N. ; DeCock, K. M. ; Bolay, F. ; Sanchez-Lockhart, M. ; Palacios, G. / Molecular evidence of sexual transmission of ebola virus. In: New England Journal of Medicine. 2015 ; Vol. 373, No. 25. pp. 2448-2454.
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AU - Schoepp, R. J.

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AU - Laney, A. S.

AU - Williams, D. E.

AU - Lo, T.

AU - Gasasira, A.

AU - Nichol, S. T.

AU - Formenty, P.

AU - Kateh, F. N.

AU - DeCock, K. M.

AU - Bolay, F.

AU - Sanchez-Lockhart, M.

AU - Palacios, G.

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