Molecular diagnosis of Burkitt's lymphoma

Sandeep S. Dave, Kai Fu, George W. Wright, Lloyd T. Lam, Philip Kluin, Evert Jan Boerma, Timothy Charles Greiner, Dennis D. Weisenburger, Andreas Rosenwald, German Ott, Hans Konrad Müller-Hermelink, Randy D. Gascoyne, Jan Delabie, Lisa M. Rimsza, Rita M. Braziel, Thomas M. Grogan, Elias Campo, Elaine S. Jaffe, Bhavana J Dave, Warren SangerMartin Bast, Julie Marie Vose, James Olen Armitage, Joseph M. Connors, Erlend B. Smeland, Stein Kvaloy, Harald Holte, Richard I. Fisher, Thomas P. Miller, Emilio Montserrat, Wyndham H. Wilson, Manisha Bahl, Hong Zhao, Liming Yang, John Powell, Richard Simon, Wing C. Chan, Louis M. Staudt

Research output: Contribution to journalArticle

631 Citations (Scopus)

Abstract

BACKGROUND: The distinction between Burkitt's lymphoma and diffuse large-B-cell lymphoma is crucial because these two types of lymphoma require different treatments. We examined whether gene-expression profiling could reliably distinguish Burkitt's lymphoma from diffuse large-B-cell lymphoma. METHODS: Tumor-biopsy specimens from 303 patients with aggressive lymphomas were profiled for gene expression and were also classified according to morphology, immunohistochemistry, and detection of the t(8;14) c-myc translocation. RESULTS: A classifier based on gene expression correctly identified all 25 pathologically verified cases of classic Burkitt's lymphoma. Burkitt's lymphoma was readily distinguished from diffuse large-B-cell lymphoma by the high level of expression of c-myc target genes, the expression of a subgroup of germinal-center B-cell genes, and the low level of expression of major-histocompatibility-complex class I genes and nuclear factor-.B target genes. Eight specimens with a pathological diagnosis of diffuse large-B-cell lymphoma had the typical gene-expression profile of Burkitt's lymphoma, suggesting they represent cases of Burkitt's lymphoma that are difficult to diagnose by current methods. Among 28 of the patients with a molecular diagnosis of Burkitt's lymphoma, the overall survival was superior among those who had received intensive chemotherapy regimens instead of lower-dose regimens. CONCLUSIONS: Gene-expression profiling is an accurate, quantitative method for distinguishing Burkitt's lymphoma from diffuse large-B-cell lymphoma.

Original languageEnglish (US)
Pages (from-to)2431-2442
Number of pages12
JournalNew England Journal of Medicine
Volume354
Issue number23
DOIs
StatePublished - Jun 8 2006

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Burkitt Lymphoma
Lymphoma, Large B-Cell, Diffuse
Gene Expression Profiling
Gene Expression
Lymphoma
MHC Class I Genes
myc Genes
Germinal Center
Major Histocompatibility Complex
Transcriptome
Genes
B-Lymphocytes
Immunohistochemistry
Biopsy
Drug Therapy
Survival

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dave, S. S., Fu, K., Wright, G. W., Lam, L. T., Kluin, P., Boerma, E. J., ... Staudt, L. M. (2006). Molecular diagnosis of Burkitt's lymphoma. New England Journal of Medicine, 354(23), 2431-2442. https://doi.org/10.1056/NEJMoa055759

Molecular diagnosis of Burkitt's lymphoma. / Dave, Sandeep S.; Fu, Kai; Wright, George W.; Lam, Lloyd T.; Kluin, Philip; Boerma, Evert Jan; Greiner, Timothy Charles; Weisenburger, Dennis D.; Rosenwald, Andreas; Ott, German; Müller-Hermelink, Hans Konrad; Gascoyne, Randy D.; Delabie, Jan; Rimsza, Lisa M.; Braziel, Rita M.; Grogan, Thomas M.; Campo, Elias; Jaffe, Elaine S.; Dave, Bhavana J; Sanger, Warren; Bast, Martin; Vose, Julie Marie; Armitage, James Olen; Connors, Joseph M.; Smeland, Erlend B.; Kvaloy, Stein; Holte, Harald; Fisher, Richard I.; Miller, Thomas P.; Montserrat, Emilio; Wilson, Wyndham H.; Bahl, Manisha; Zhao, Hong; Yang, Liming; Powell, John; Simon, Richard; Chan, Wing C.; Staudt, Louis M.

In: New England Journal of Medicine, Vol. 354, No. 23, 08.06.2006, p. 2431-2442.

Research output: Contribution to journalArticle

Dave, SS, Fu, K, Wright, GW, Lam, LT, Kluin, P, Boerma, EJ, Greiner, TC, Weisenburger, DD, Rosenwald, A, Ott, G, Müller-Hermelink, HK, Gascoyne, RD, Delabie, J, Rimsza, LM, Braziel, RM, Grogan, TM, Campo, E, Jaffe, ES, Dave, BJ, Sanger, W, Bast, M, Vose, JM, Armitage, JO, Connors, JM, Smeland, EB, Kvaloy, S, Holte, H, Fisher, RI, Miller, TP, Montserrat, E, Wilson, WH, Bahl, M, Zhao, H, Yang, L, Powell, J, Simon, R, Chan, WC & Staudt, LM 2006, 'Molecular diagnosis of Burkitt's lymphoma', New England Journal of Medicine, vol. 354, no. 23, pp. 2431-2442. https://doi.org/10.1056/NEJMoa055759
Dave SS, Fu K, Wright GW, Lam LT, Kluin P, Boerma EJ et al. Molecular diagnosis of Burkitt's lymphoma. New England Journal of Medicine. 2006 Jun 8;354(23):2431-2442. https://doi.org/10.1056/NEJMoa055759
Dave, Sandeep S. ; Fu, Kai ; Wright, George W. ; Lam, Lloyd T. ; Kluin, Philip ; Boerma, Evert Jan ; Greiner, Timothy Charles ; Weisenburger, Dennis D. ; Rosenwald, Andreas ; Ott, German ; Müller-Hermelink, Hans Konrad ; Gascoyne, Randy D. ; Delabie, Jan ; Rimsza, Lisa M. ; Braziel, Rita M. ; Grogan, Thomas M. ; Campo, Elias ; Jaffe, Elaine S. ; Dave, Bhavana J ; Sanger, Warren ; Bast, Martin ; Vose, Julie Marie ; Armitage, James Olen ; Connors, Joseph M. ; Smeland, Erlend B. ; Kvaloy, Stein ; Holte, Harald ; Fisher, Richard I. ; Miller, Thomas P. ; Montserrat, Emilio ; Wilson, Wyndham H. ; Bahl, Manisha ; Zhao, Hong ; Yang, Liming ; Powell, John ; Simon, Richard ; Chan, Wing C. ; Staudt, Louis M. / Molecular diagnosis of Burkitt's lymphoma. In: New England Journal of Medicine. 2006 ; Vol. 354, No. 23. pp. 2431-2442.
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abstract = "BACKGROUND: The distinction between Burkitt's lymphoma and diffuse large-B-cell lymphoma is crucial because these two types of lymphoma require different treatments. We examined whether gene-expression profiling could reliably distinguish Burkitt's lymphoma from diffuse large-B-cell lymphoma. METHODS: Tumor-biopsy specimens from 303 patients with aggressive lymphomas were profiled for gene expression and were also classified according to morphology, immunohistochemistry, and detection of the t(8;14) c-myc translocation. RESULTS: A classifier based on gene expression correctly identified all 25 pathologically verified cases of classic Burkitt's lymphoma. Burkitt's lymphoma was readily distinguished from diffuse large-B-cell lymphoma by the high level of expression of c-myc target genes, the expression of a subgroup of germinal-center B-cell genes, and the low level of expression of major-histocompatibility-complex class I genes and nuclear factor-.B target genes. Eight specimens with a pathological diagnosis of diffuse large-B-cell lymphoma had the typical gene-expression profile of Burkitt's lymphoma, suggesting they represent cases of Burkitt's lymphoma that are difficult to diagnose by current methods. Among 28 of the patients with a molecular diagnosis of Burkitt's lymphoma, the overall survival was superior among those who had received intensive chemotherapy regimens instead of lower-dose regimens. CONCLUSIONS: Gene-expression profiling is an accurate, quantitative method for distinguishing Burkitt's lymphoma from diffuse large-B-cell lymphoma.",
author = "Dave, {Sandeep S.} and Kai Fu and Wright, {George W.} and Lam, {Lloyd T.} and Philip Kluin and Boerma, {Evert Jan} and Greiner, {Timothy Charles} and Weisenburger, {Dennis D.} and Andreas Rosenwald and German Ott and M{\"u}ller-Hermelink, {Hans Konrad} and Gascoyne, {Randy D.} and Jan Delabie and Rimsza, {Lisa M.} and Braziel, {Rita M.} and Grogan, {Thomas M.} and Elias Campo and Jaffe, {Elaine S.} and Dave, {Bhavana J} and Warren Sanger and Martin Bast and Vose, {Julie Marie} and Armitage, {James Olen} and Connors, {Joseph M.} and Smeland, {Erlend B.} and Stein Kvaloy and Harald Holte and Fisher, {Richard I.} and Miller, {Thomas P.} and Emilio Montserrat and Wilson, {Wyndham H.} and Manisha Bahl and Hong Zhao and Liming Yang and John Powell and Richard Simon and Chan, {Wing C.} and Staudt, {Louis M.}",
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T1 - Molecular diagnosis of Burkitt's lymphoma

AU - Dave, Sandeep S.

AU - Fu, Kai

AU - Wright, George W.

AU - Lam, Lloyd T.

AU - Kluin, Philip

AU - Boerma, Evert Jan

AU - Greiner, Timothy Charles

AU - Weisenburger, Dennis D.

AU - Rosenwald, Andreas

AU - Ott, German

AU - Müller-Hermelink, Hans Konrad

AU - Gascoyne, Randy D.

AU - Delabie, Jan

AU - Rimsza, Lisa M.

AU - Braziel, Rita M.

AU - Grogan, Thomas M.

AU - Campo, Elias

AU - Jaffe, Elaine S.

AU - Dave, Bhavana J

AU - Sanger, Warren

AU - Bast, Martin

AU - Vose, Julie Marie

AU - Armitage, James Olen

AU - Connors, Joseph M.

AU - Smeland, Erlend B.

AU - Kvaloy, Stein

AU - Holte, Harald

AU - Fisher, Richard I.

AU - Miller, Thomas P.

AU - Montserrat, Emilio

AU - Wilson, Wyndham H.

AU - Bahl, Manisha

AU - Zhao, Hong

AU - Yang, Liming

AU - Powell, John

AU - Simon, Richard

AU - Chan, Wing C.

AU - Staudt, Louis M.

PY - 2006/6/8

Y1 - 2006/6/8

N2 - BACKGROUND: The distinction between Burkitt's lymphoma and diffuse large-B-cell lymphoma is crucial because these two types of lymphoma require different treatments. We examined whether gene-expression profiling could reliably distinguish Burkitt's lymphoma from diffuse large-B-cell lymphoma. METHODS: Tumor-biopsy specimens from 303 patients with aggressive lymphomas were profiled for gene expression and were also classified according to morphology, immunohistochemistry, and detection of the t(8;14) c-myc translocation. RESULTS: A classifier based on gene expression correctly identified all 25 pathologically verified cases of classic Burkitt's lymphoma. Burkitt's lymphoma was readily distinguished from diffuse large-B-cell lymphoma by the high level of expression of c-myc target genes, the expression of a subgroup of germinal-center B-cell genes, and the low level of expression of major-histocompatibility-complex class I genes and nuclear factor-.B target genes. Eight specimens with a pathological diagnosis of diffuse large-B-cell lymphoma had the typical gene-expression profile of Burkitt's lymphoma, suggesting they represent cases of Burkitt's lymphoma that are difficult to diagnose by current methods. Among 28 of the patients with a molecular diagnosis of Burkitt's lymphoma, the overall survival was superior among those who had received intensive chemotherapy regimens instead of lower-dose regimens. CONCLUSIONS: Gene-expression profiling is an accurate, quantitative method for distinguishing Burkitt's lymphoma from diffuse large-B-cell lymphoma.

AB - BACKGROUND: The distinction between Burkitt's lymphoma and diffuse large-B-cell lymphoma is crucial because these two types of lymphoma require different treatments. We examined whether gene-expression profiling could reliably distinguish Burkitt's lymphoma from diffuse large-B-cell lymphoma. METHODS: Tumor-biopsy specimens from 303 patients with aggressive lymphomas were profiled for gene expression and were also classified according to morphology, immunohistochemistry, and detection of the t(8;14) c-myc translocation. RESULTS: A classifier based on gene expression correctly identified all 25 pathologically verified cases of classic Burkitt's lymphoma. Burkitt's lymphoma was readily distinguished from diffuse large-B-cell lymphoma by the high level of expression of c-myc target genes, the expression of a subgroup of germinal-center B-cell genes, and the low level of expression of major-histocompatibility-complex class I genes and nuclear factor-.B target genes. Eight specimens with a pathological diagnosis of diffuse large-B-cell lymphoma had the typical gene-expression profile of Burkitt's lymphoma, suggesting they represent cases of Burkitt's lymphoma that are difficult to diagnose by current methods. Among 28 of the patients with a molecular diagnosis of Burkitt's lymphoma, the overall survival was superior among those who had received intensive chemotherapy regimens instead of lower-dose regimens. CONCLUSIONS: Gene-expression profiling is an accurate, quantitative method for distinguishing Burkitt's lymphoma from diffuse large-B-cell lymphoma.

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