Molecular diagnosis and outcome prediction in diffuse large B-cell lymphoma and other subtypes of lymphoma

Karen Dybkaer, Javeed Iqbal, Guimei Zhou, Wing C. Chan

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Lymphoid malignancies are grouped and characterized by their morphology, immunophenotype, and genetic aberrations to help establish a diagnosis. Use of microarray technology enables the simultaneous determination of expression levels for thousands of genes, providing an additional powerful tool for improving disease classification. In this review, recent studies of diffuse large B-cell lymphoma (DLBCL), primary mediastinal large B-cell lymphoma, mantle cell lymphoma (MCL), and follicular lymphoma are highlighted, and the impact of gene expression profiling on the molecular diagnosis of these diseases is discussed. Based on microarray-generated gene expression profiles, outcome predictors were constructed for DLBCL and MCL. Specific expression patterns of a limited number of genes at the time of diagnosis were linked to overall survival in DLBCL and MCL. Such predictors of prognosis may eventually lead to risk-adjusted treatment of lymphomas. Specific therapeutic targets may also emerge with increased insight into the molecular features of the different lymphomas, thus illustrating the usefulness of gene expression profiling not only to improve diagnosis and classification but also to generate prognostic indicators and targets for the therapy.

Original languageEnglish (US)
Pages (from-to)19-28
Number of pages10
JournalClinical lymphoma
Volume5
Issue number1
DOIs
StatePublished - Jun 2004

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Lymphoma, Large B-Cell, Diffuse
Mantle-Cell Lymphoma
Lymphoma
Gene Expression Profiling
B-Lymphocytes
Follicular Lymphoma
B-Cell Lymphoma
Transcriptome
Genes
Technology
Therapeutics
Neoplasms

Keywords

  • Classification
  • Gene expression profiling
  • Microarray
  • Prognosis
  • Therapeutic target

ASJC Scopus subject areas

  • Cancer Research

Cite this

Molecular diagnosis and outcome prediction in diffuse large B-cell lymphoma and other subtypes of lymphoma. / Dybkaer, Karen; Iqbal, Javeed; Zhou, Guimei; Chan, Wing C.

In: Clinical lymphoma, Vol. 5, No. 1, 06.2004, p. 19-28.

Research output: Contribution to journalReview article

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AB - Lymphoid malignancies are grouped and characterized by their morphology, immunophenotype, and genetic aberrations to help establish a diagnosis. Use of microarray technology enables the simultaneous determination of expression levels for thousands of genes, providing an additional powerful tool for improving disease classification. In this review, recent studies of diffuse large B-cell lymphoma (DLBCL), primary mediastinal large B-cell lymphoma, mantle cell lymphoma (MCL), and follicular lymphoma are highlighted, and the impact of gene expression profiling on the molecular diagnosis of these diseases is discussed. Based on microarray-generated gene expression profiles, outcome predictors were constructed for DLBCL and MCL. Specific expression patterns of a limited number of genes at the time of diagnosis were linked to overall survival in DLBCL and MCL. Such predictors of prognosis may eventually lead to risk-adjusted treatment of lymphomas. Specific therapeutic targets may also emerge with increased insight into the molecular features of the different lymphomas, thus illustrating the usefulness of gene expression profiling not only to improve diagnosis and classification but also to generate prognostic indicators and targets for the therapy.

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