Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component

Carlo Visco, Sylvia Hoeller, Jeffrey T. Malik, Zijun Y. Xu-Monette, Michele L. Wiggins, Jessica Liu, Warren G. Sanger, Zhongfeng Liu, Julie Chang, Erik A. Ranheim, Joel F. Gradowski, Sergio Serrano, Huan You Wang, Qingquan Liu, Sandeep Dave, Brian Olsen, Randy D. Gascoyne, Elias Campo, Steven H. Swerdlow, Wing C. ChanAlexander Tzankov, Ken H. Young

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The normal counterparts of mantle cell lymphoma (MCL) are naive, quiescent B cells that have not been processed through the germinal center (GC). For this reason, although lymphomas arising from GC or post-GC B cells often exhibit plasmacytic differentiation, MCL rarely presents with plasmacytic features. Seven cases of MCL with a monotypic plasma cell (PC) population were collected from 6 centers and were studied by immunohistochemistry, fluorescence immunophenotyping and interphase cytogenetics as a tool for the investigation of neoplasms analysis, capillary gel electrophoresis, and restriction fragment length polymorphism of immunoglobulin heavy chain analysis of microdissections of each of the MCL and PC populations to assess their clonal relationship. The clinical presentation was rather unusual compared with typical MCL, with 2 cases arising from the extranodal soft tissues of the head. All MCL cases were morphologically and immunohistochemically typical, bearing the t(11;14)(q13;q32). In all cases, the PC population was clonal. In 5 of the 7 cases, the MCL and PC clones showed identical restriction fragments, indicating a common clonal origin of the neoplastic population. The 2 cases with clonal diversity denoted the coexistence of 2 different tumors in a composite lymphoma/PC neoplasm. Our findings suggest that MCL can present with a PC component that is often clonally related to the lymphoma, representing a rare but unique biological variant of this tumor.

Original languageEnglish (US)
Pages (from-to)177-189
Number of pages13
JournalAmerican Journal of Surgical Pathology
Volume35
Issue number2
DOIs
StatePublished - Feb 1 2011

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Mantle-Cell Lymphoma
Cellular Structures
Plasma Cells
Germinal Center
Population
Composite Lymphoma
Lymphoma
Plasma Cell Neoplasms
B-Lymphocytes
Immunophenotyping
Neoplasms
Microdissection
Immunoglobulin Heavy Chains
Interphase
Capillary Electrophoresis
Cytogenetics
Restriction Fragment Length Polymorphisms
Clone Cells
Fluorescence
Gels

Keywords

  • cyclin D1
  • mantle cell lymphoma
  • monotypic plasma cells
  • plasma cells
  • plasmacytic differentiation

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Visco, C., Hoeller, S., Malik, J. T., Xu-Monette, Z. Y., Wiggins, M. L., Liu, J., ... Young, K. H. (2011). Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component. American Journal of Surgical Pathology, 35(2), 177-189. https://doi.org/10.1097/PAS.0b013e3182049a9c

Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component. / Visco, Carlo; Hoeller, Sylvia; Malik, Jeffrey T.; Xu-Monette, Zijun Y.; Wiggins, Michele L.; Liu, Jessica; Sanger, Warren G.; Liu, Zhongfeng; Chang, Julie; Ranheim, Erik A.; Gradowski, Joel F.; Serrano, Sergio; Wang, Huan You; Liu, Qingquan; Dave, Sandeep; Olsen, Brian; Gascoyne, Randy D.; Campo, Elias; Swerdlow, Steven H.; Chan, Wing C.; Tzankov, Alexander; Young, Ken H.

In: American Journal of Surgical Pathology, Vol. 35, No. 2, 01.02.2011, p. 177-189.

Research output: Contribution to journalArticle

Visco, C, Hoeller, S, Malik, JT, Xu-Monette, ZY, Wiggins, ML, Liu, J, Sanger, WG, Liu, Z, Chang, J, Ranheim, EA, Gradowski, JF, Serrano, S, Wang, HY, Liu, Q, Dave, S, Olsen, B, Gascoyne, RD, Campo, E, Swerdlow, SH, Chan, WC, Tzankov, A & Young, KH 2011, 'Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component', American Journal of Surgical Pathology, vol. 35, no. 2, pp. 177-189. https://doi.org/10.1097/PAS.0b013e3182049a9c
Visco, Carlo ; Hoeller, Sylvia ; Malik, Jeffrey T. ; Xu-Monette, Zijun Y. ; Wiggins, Michele L. ; Liu, Jessica ; Sanger, Warren G. ; Liu, Zhongfeng ; Chang, Julie ; Ranheim, Erik A. ; Gradowski, Joel F. ; Serrano, Sergio ; Wang, Huan You ; Liu, Qingquan ; Dave, Sandeep ; Olsen, Brian ; Gascoyne, Randy D. ; Campo, Elias ; Swerdlow, Steven H. ; Chan, Wing C. ; Tzankov, Alexander ; Young, Ken H. / Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component. In: American Journal of Surgical Pathology. 2011 ; Vol. 35, No. 2. pp. 177-189.
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AU - Sanger, Warren G.

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AU - Ranheim, Erik A.

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