Molecular approaches to enteroviral diagnosis in idiopathic cardiomyopathy and myocarditis

Steven Tracy, Volker Wiegand, Bruce McManus, Charles Gauntt, Mark Pallansch, Melinda Beck, Nora Chapman

Research output: Contribution to journalReview article

87 Citations (Scopus)

Abstract

Enteroviruses are thought to be etiologic agents in some cases of human myocarditis and dilated cardiomyopathy. Murine models of acute coxsackievirus E3 myocarditis implicate coxsackie E viruses as possible causes of human myocarditis. Indirect evidence implicating enteroviruses as causative agents in human heart disease derives from serologic studies. More recently, direct evidence for enteroviral presence in diseased human heart tissues has been obtained by nucleic acid hybridization analyses. Although the data suggest that enteroviral infections may be associated with 18% to 50% of cases of myocarditis or dilated cardiomyopathy, or both, causality has not been established. Unanswered questions remain regarding the specific identity of the enteroviral genomes detected in the human heart and the potential for enteroviruses to persist in the heart.

Original languageEnglish (US)
Pages (from-to)1688-1694
Number of pages7
JournalJournal of the American College of Cardiology
Volume15
Issue number7
DOIs
StatePublished - Jun 1990

Fingerprint

Enterovirus
Myocarditis
Cardiomyopathies
Dilated Cardiomyopathy
Heart Diseases
Nucleic Acid Hybridization
Causality
Genome
Infection

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Molecular approaches to enteroviral diagnosis in idiopathic cardiomyopathy and myocarditis. / Tracy, Steven; Wiegand, Volker; McManus, Bruce; Gauntt, Charles; Pallansch, Mark; Beck, Melinda; Chapman, Nora.

In: Journal of the American College of Cardiology, Vol. 15, No. 7, 06.1990, p. 1688-1694.

Research output: Contribution to journalReview article

Tracy, S, Wiegand, V, McManus, B, Gauntt, C, Pallansch, M, Beck, M & Chapman, N 1990, 'Molecular approaches to enteroviral diagnosis in idiopathic cardiomyopathy and myocarditis', Journal of the American College of Cardiology, vol. 15, no. 7, pp. 1688-1694. https://doi.org/10.1016/0735-1097(90)92846-T
Tracy, Steven ; Wiegand, Volker ; McManus, Bruce ; Gauntt, Charles ; Pallansch, Mark ; Beck, Melinda ; Chapman, Nora. / Molecular approaches to enteroviral diagnosis in idiopathic cardiomyopathy and myocarditis. In: Journal of the American College of Cardiology. 1990 ; Vol. 15, No. 7. pp. 1688-1694.
@article{c770b41fd01e45fd8b3c425c63a35a74,
title = "Molecular approaches to enteroviral diagnosis in idiopathic cardiomyopathy and myocarditis",
abstract = "Enteroviruses are thought to be etiologic agents in some cases of human myocarditis and dilated cardiomyopathy. Murine models of acute coxsackievirus E3 myocarditis implicate coxsackie E viruses as possible causes of human myocarditis. Indirect evidence implicating enteroviruses as causative agents in human heart disease derives from serologic studies. More recently, direct evidence for enteroviral presence in diseased human heart tissues has been obtained by nucleic acid hybridization analyses. Although the data suggest that enteroviral infections may be associated with 18{\%} to 50{\%} of cases of myocarditis or dilated cardiomyopathy, or both, causality has not been established. Unanswered questions remain regarding the specific identity of the enteroviral genomes detected in the human heart and the potential for enteroviruses to persist in the heart.",
author = "Steven Tracy and Volker Wiegand and Bruce McManus and Charles Gauntt and Mark Pallansch and Melinda Beck and Nora Chapman",
year = "1990",
month = "6",
doi = "10.1016/0735-1097(90)92846-T",
language = "English (US)",
volume = "15",
pages = "1688--1694",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "7",

}

TY - JOUR

T1 - Molecular approaches to enteroviral diagnosis in idiopathic cardiomyopathy and myocarditis

AU - Tracy, Steven

AU - Wiegand, Volker

AU - McManus, Bruce

AU - Gauntt, Charles

AU - Pallansch, Mark

AU - Beck, Melinda

AU - Chapman, Nora

PY - 1990/6

Y1 - 1990/6

N2 - Enteroviruses are thought to be etiologic agents in some cases of human myocarditis and dilated cardiomyopathy. Murine models of acute coxsackievirus E3 myocarditis implicate coxsackie E viruses as possible causes of human myocarditis. Indirect evidence implicating enteroviruses as causative agents in human heart disease derives from serologic studies. More recently, direct evidence for enteroviral presence in diseased human heart tissues has been obtained by nucleic acid hybridization analyses. Although the data suggest that enteroviral infections may be associated with 18% to 50% of cases of myocarditis or dilated cardiomyopathy, or both, causality has not been established. Unanswered questions remain regarding the specific identity of the enteroviral genomes detected in the human heart and the potential for enteroviruses to persist in the heart.

AB - Enteroviruses are thought to be etiologic agents in some cases of human myocarditis and dilated cardiomyopathy. Murine models of acute coxsackievirus E3 myocarditis implicate coxsackie E viruses as possible causes of human myocarditis. Indirect evidence implicating enteroviruses as causative agents in human heart disease derives from serologic studies. More recently, direct evidence for enteroviral presence in diseased human heart tissues has been obtained by nucleic acid hybridization analyses. Although the data suggest that enteroviral infections may be associated with 18% to 50% of cases of myocarditis or dilated cardiomyopathy, or both, causality has not been established. Unanswered questions remain regarding the specific identity of the enteroviral genomes detected in the human heart and the potential for enteroviruses to persist in the heart.

UR - http://www.scopus.com/inward/record.url?scp=0025282732&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025282732&partnerID=8YFLogxK

U2 - 10.1016/0735-1097(90)92846-T

DO - 10.1016/0735-1097(90)92846-T

M3 - Review article

C2 - 2161026

AN - SCOPUS:0025282732

VL - 15

SP - 1688

EP - 1694

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 7

ER -