Molecular analyses of human immunodeficiency virus type 1 V3 region quasispecies derived from plasma and peripheral blood mononuclear cells of the first long-term-nonprogressing mother and child pair

Bin Wang, Ying Chun Ge, Rafael Jozwiak, Wayne Bolton, Pamela Palasanthiran, John Ziegler, Joon Chang, Shi Hua Xiang, Anthony L. Cunningham, Nitin K. Saksena

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Abstract

Molecular analyses were done for the V3 region quasispecies of human immunodeficiency virus type 1 (HIV-1) strains from plasma and peripheral blood mononuclear cells of the first HIV-1-infected long-term-nonprogressing mother-child pair whose members have survived for > 13 years with stable CD4 T cell counts. There was a predominance of lower V3 loop charge and the absence of genotypic changes that are critical in phenotypic determination and tropism during HIV-1 infection. The intrahost genetic diversity between HIV-1 strains from the mother-child pair compared with HIV-1 strains from slow and rapid progressors suggested that a high genetic heterogeneity in HIV-1 strains from this HIV-l-infected long-term-nonprogressing mother and child pair was directly proportional to the length of their immunocompetent period.

Original languageEnglish (US)
Pages (from-to)1510-1515
Number of pages6
JournalJournal of Infectious Diseases
Volume175
Issue number6
DOIs
Publication statusPublished - Jan 1 1997

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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