Molecular analyses of human immunodeficiency virus type 1 V3 region quasispecies derived from plasma and peripheral blood mononuclear cells of the first long-term-nonprogressing mother and child pair

Bin Wang, Ying Chun Ge, Rafael Jozwiak, Wayne Bolton, Pamela Palasanthiran, John Ziegler, Joon Chang, Shi Hua Xiang, Anthony L. Cunningham, Nitin K. Saksena

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Molecular analyses were done for the V3 region quasispecies of human immunodeficiency virus type 1 (HIV-1) strains from plasma and peripheral blood mononuclear cells of the first HIV-1-infected long-term-nonprogressing mother-child pair whose members have survived for > 13 years with stable CD4 T cell counts. There was a predominance of lower V3 loop charge and the absence of genotypic changes that are critical in phenotypic determination and tropism during HIV-1 infection. The intrahost genetic diversity between HIV-1 strains from the mother-child pair compared with HIV-1 strains from slow and rapid progressors suggested that a high genetic heterogeneity in HIV-1 strains from this HIV-l-infected long-term-nonprogressing mother and child pair was directly proportional to the length of their immunocompetent period.

Original languageEnglish (US)
Pages (from-to)1510-1515
Number of pages6
JournalJournal of Infectious Diseases
Volume175
Issue number6
DOIs
StatePublished - Jan 1 1997

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HIV-1
Blood Cells
Mothers
Tropism
Genetic Heterogeneity
Virus Diseases
CD4 Lymphocyte Count
HIV
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Molecular analyses of human immunodeficiency virus type 1 V3 region quasispecies derived from plasma and peripheral blood mononuclear cells of the first long-term-nonprogressing mother and child pair. / Wang, Bin; Ge, Ying Chun; Jozwiak, Rafael; Bolton, Wayne; Palasanthiran, Pamela; Ziegler, John; Chang, Joon; Xiang, Shi Hua; Cunningham, Anthony L.; Saksena, Nitin K.

In: Journal of Infectious Diseases, Vol. 175, No. 6, 01.01.1997, p. 1510-1515.

Research output: Contribution to journalArticle

Wang, Bin ; Ge, Ying Chun ; Jozwiak, Rafael ; Bolton, Wayne ; Palasanthiran, Pamela ; Ziegler, John ; Chang, Joon ; Xiang, Shi Hua ; Cunningham, Anthony L. ; Saksena, Nitin K. / Molecular analyses of human immunodeficiency virus type 1 V3 region quasispecies derived from plasma and peripheral blood mononuclear cells of the first long-term-nonprogressing mother and child pair. In: Journal of Infectious Diseases. 1997 ; Vol. 175, No. 6. pp. 1510-1515.
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AU - Bolton, Wayne

AU - Palasanthiran, Pamela

AU - Ziegler, John

AU - Chang, Joon

AU - Xiang, Shi Hua

AU - Cunningham, Anthony L.

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