Modulation of oxidative stress by alcohol

Tomáš Zima, Emanuele Albano, Magnus Ingelman-Sundberg, Gavin E. Arteel, Geoffrey Milton Thiele, Lynell Warren Klassen, Albert Y. Sun

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

It is well established that reactive oxygen species (ROS) and reactive nitrogen species (RNS) are involved in causing acute and chronic alcohol toxicity. Biochemical signs of oxidative damage can be detected in experimental animals exposed to ethanol as well as in alcoholic patients. Ethanol-induced oxidative stress is the consequence of the combined effect of an increased production of ROS by the mitochondria and the alcohol-inducible cytochrome P-4502E1 (CYP2E1) and the impairment of antioxidant defenses. Furthermore, by promoting the activation of Kuppfer cells, ethanol causes the release of cytokines, ROS, and RNS. The mechanisms by which oxidative damage contribute to alcohol toxicity include direct hepatocellular damage, induction of apoptosis, and the stimulation of collagen deposition by hepatic stellate cells. In addition, lipid peroxidation products and, particularly acetaldehydemalondialdehyde adducts, along with immune reactions triggered by oxidative stress, might also contribute to perpetuate hepatic inflammation. The implication of oxidative stress in alcohol liver damage gives a rationale to the clinical application of therapies aimed to prevent or reduce ethanol-induced oxidative damage by antioxidant compounds.

Original languageEnglish (US)
Pages (from-to)1060-1065
Number of pages6
JournalAlcoholism: Clinical and Experimental Research
Volume29
Issue number6
DOIs
StatePublished - Jun 1 2005

Fingerprint

Oxidative stress
Oxidative Stress
Ethanol
Alcohols
Modulation
Reactive Nitrogen Species
Reactive Oxygen Species
Toxicity
Antioxidants
Antigen-antibody reactions
Hepatic Stellate Cells
Mitochondria
Liver
Alcoholics
Cytochromes
Lipid Peroxidation
Animals
Collagen
Chemical activation
Apoptosis

Keywords

  • Alcoholic liver disease
  • CYP2E1
  • Kupffer cells
  • Lipid peroxidation
  • Oxidative stress

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Cite this

Modulation of oxidative stress by alcohol. / Zima, Tomáš; Albano, Emanuele; Ingelman-Sundberg, Magnus; Arteel, Gavin E.; Thiele, Geoffrey Milton; Klassen, Lynell Warren; Sun, Albert Y.

In: Alcoholism: Clinical and Experimental Research, Vol. 29, No. 6, 01.06.2005, p. 1060-1065.

Research output: Contribution to journalArticle

Zima, Tomáš ; Albano, Emanuele ; Ingelman-Sundberg, Magnus ; Arteel, Gavin E. ; Thiele, Geoffrey Milton ; Klassen, Lynell Warren ; Sun, Albert Y. / Modulation of oxidative stress by alcohol. In: Alcoholism: Clinical and Experimental Research. 2005 ; Vol. 29, No. 6. pp. 1060-1065.
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