Modulation of ionotropic glutamate receptors and acid-sensing ion channels by nitric oxide

John Q. Wang, Xiang Ping Chu, Ming Lei Guo, Dao Zhong Jin, Bing Xue, Thomas J. Berry, Eugene E. Fibuch, Li Min Mao

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Ionotropic glutamate receptors (iGluR) are ligand-gated ion channels and are densely expressed in broad areas of mammalian brains. Like iGluRs, acid-sensing ion channels (ASIC) are ligand (H +)-gated channels and are enriched in brain cells and peripheral sensory neurons. Both ion channels are enriched at excitatory synaptic sites, functionally coupled to each other, and subject to the modulation by a variety of signaling molecules. Central among them is a gasotransmitter, nitric oxide (NO). Available data show that NO activity-dependently modulates iGluRs and ASICs via either a direct or an indirect pathway. The former involves a NO-based and cGMP-independent post-translational modification (S-nitrosylation) of extracellular cysteine residues in channel subunits or channel-interacting proteins. The latter is achieved by NO activation of soluble guanylyl cyclase, which in turn triggers an intracellular cGMP-sensitive cascade to indirectly modulate iGluRs and ASICs. The NO modification is usually dynamic and reversible. Modified channels undergo significant, interrelated changes in biochemistry and electrophysiology. Since NO synthesis is enhanced in various neurological disorders, the NO modulation of iGluRs and ASICs is believed to be directly linked to the pathogenesis of these disorders. This review summarizes the direct and indirect modifications of iGluRs and ASICs by NO and analyzes the role of the NO-iGluR and NO-ASIC coupling in cell signaling and in the pathogenesis of certain related neurological diseases.

Original languageEnglish (US)
Article numberArticle 164
JournalFrontiers in Physiology
Volume3 MAY
DOIs
StatePublished - Sep 24 2012

Fingerprint

Acid Sensing Ion Channels
Ionotropic Glutamate Receptors
Nitric Oxide
Ligand-Gated Ion Channels
Gasotransmitters
Nitric Acid
Electrophysiology
Brain
Sensory Receptor Cells
Post Translational Protein Processing
Nervous System Diseases
Ion Channels
Biochemistry
Cysteine

Keywords

  • AMPA
  • ASIC
  • Gasotransmitter
  • NMDA
  • NOS
  • Nitrosylation
  • No
  • cGMP

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Modulation of ionotropic glutamate receptors and acid-sensing ion channels by nitric oxide. / Wang, John Q.; Chu, Xiang Ping; Guo, Ming Lei; Jin, Dao Zhong; Xue, Bing; Berry, Thomas J.; Fibuch, Eugene E.; Mao, Li Min.

In: Frontiers in Physiology, Vol. 3 MAY, Article 164, 24.09.2012.

Research output: Contribution to journalReview article

Wang, John Q. ; Chu, Xiang Ping ; Guo, Ming Lei ; Jin, Dao Zhong ; Xue, Bing ; Berry, Thomas J. ; Fibuch, Eugene E. ; Mao, Li Min. / Modulation of ionotropic glutamate receptors and acid-sensing ion channels by nitric oxide. In: Frontiers in Physiology. 2012 ; Vol. 3 MAY.
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