Modulation of gastric acid secretion by adenosine in conscious rats

G. B. Glavin, V. S. Westerberg, J. D. Geiger

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Abstract

Basal (nonstimulated) gastric acid output was determined in conscious rats fitted with indwelling gastric cannulae. The adenosine deaminase resistant analog of adenosine, R-phenylisopropyladenosine, elevated intraluminal pH beyond 7.0 and decreased gastric acid secretion when given at doses of 0.10 or 1.0 mg/kg, while S-phenylisopropyladenosine at similar doses did not affect either gastric acid output or pH. The potent adenosine receptor antagonist, 8-phenyltheophylline, given at doses of 0.1,. 1.0, and 2.5 mg/kg augmented acid output and, at doses of 0.01, 0.1, 1.0, and 2.5 mg/kg, blocked the acid-reducing effect of R-phenylisopropyladenosine (0.1 mg/kg). These data suggest that adenosine systems may be important regulators of gastric function.

Original languageEnglish (US)
Pages (from-to)1182-1185
Number of pages4
JournalCanadian journal of physiology and pharmacology
Volume65
Issue number6
DOIs
StatePublished - Jan 1 1987

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ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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