Modulation of estrogen action in the rat pituitary and mammary glands by dietary energy consumption

Thomas J. Spady, Djuana M E Harvell, Athena Lemus-Wilson, Tracy E. Strecker, Karen L. Pennington, Eric A. Vander Woude, Diane F. Birt, Rodney D McComb, James D. Shull

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We are investigating the mechanisms through which estrogens induce development of prolactin (PRL)-producing pituitary tumors and mammary carcinomas in rats and how these mechanisms are affected by dietary energy consumption. The hypothesis under examination is that dietary energy restriction inhibits tumorigenesis in estrogen-responsive tissues by altering cellular responsiveness to estrogenic hormones. In the Fischer 344 (F344) rat strain, a 40% restriction of energy consumption virtually abolishes development of estrogen-induced pituitary tumors. Inhibition of pituitary tumorigenesis in the F344 strain by energy restriction results from modulation of estrogen regulation of cell survival, not cell proliferation. In contrast, energy restriction has no inhibitory effect on estrogen-induced pituitary tumor development in the ACI rat strain. However energy restriction markedly inhibits induction of mammary carcinomas in female ACI rats treated with 17β-estradiol. Data presented herein indicate that dietary energy restriction modulates the responsiveness of specific cell populations to estrogenic hormones and thereby inhibits estrogen-induced tumorigenesis in a manner specific to both rat strain and tissue.

Original languageEnglish (US)
JournalJournal of Nutrition
Volume129
Issue number2 SUPPL.
StatePublished - Feb 15 1999

Fingerprint

pituitary gland
Pituitary Gland
Human Mammary Glands
mammary glands
estrogens
Estrogens
Pituitary Neoplasms
rats
Inbred ACI Rats
carcinogenesis
energy
Carcinogenesis
breast neoplasms
neoplasms
hormones
Hormones
Breast Neoplasms
Inbred F344 Rats
prolactin
Prolactin

Keywords

  • Dietary energy restriction
  • Estrogen
  • Mammary cancer
  • Pituitary tumor
  • Prolactin
  • Rats

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Spady, T. J., Harvell, D. M. E., Lemus-Wilson, A., Strecker, T. E., Pennington, K. L., Vander Woude, E. A., ... Shull, J. D. (1999). Modulation of estrogen action in the rat pituitary and mammary glands by dietary energy consumption. Journal of Nutrition, 129(2 SUPPL.).

Modulation of estrogen action in the rat pituitary and mammary glands by dietary energy consumption. / Spady, Thomas J.; Harvell, Djuana M E; Lemus-Wilson, Athena; Strecker, Tracy E.; Pennington, Karen L.; Vander Woude, Eric A.; Birt, Diane F.; McComb, Rodney D; Shull, James D.

In: Journal of Nutrition, Vol. 129, No. 2 SUPPL., 15.02.1999.

Research output: Contribution to journalArticle

Spady, TJ, Harvell, DME, Lemus-Wilson, A, Strecker, TE, Pennington, KL, Vander Woude, EA, Birt, DF, McComb, RD & Shull, JD 1999, 'Modulation of estrogen action in the rat pituitary and mammary glands by dietary energy consumption', Journal of Nutrition, vol. 129, no. 2 SUPPL..
Spady TJ, Harvell DME, Lemus-Wilson A, Strecker TE, Pennington KL, Vander Woude EA et al. Modulation of estrogen action in the rat pituitary and mammary glands by dietary energy consumption. Journal of Nutrition. 1999 Feb 15;129(2 SUPPL.).
Spady, Thomas J. ; Harvell, Djuana M E ; Lemus-Wilson, Athena ; Strecker, Tracy E. ; Pennington, Karen L. ; Vander Woude, Eric A. ; Birt, Diane F. ; McComb, Rodney D ; Shull, James D. / Modulation of estrogen action in the rat pituitary and mammary glands by dietary energy consumption. In: Journal of Nutrition. 1999 ; Vol. 129, No. 2 SUPPL.
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