Modulation of Cellular Response to Arsenic Trioxide Toxicity by Resveratrol

Bodhisattwa Mondal, Hongxia Chen, Weihua Wen, Ercole Cavalieri, Eleanor G Rogan, Muhammad Zahid

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Arsenic trioxide (As2O3) is an environmental carcinogen and a putative endocrine disruptor. Resveratrol has been shown to reverse As2O3-induced oxidative damage. In immortalized but nontransformed estrogen receptor α-negative human breast cells (MCF10A), we observed that 25 μM resveratrol ameliorated As2O3-induced cytotoxicity. As2O3, in the presence or absence of 25 μM resveratrol, induced quinone reductase (NAD(P)H quinone dehydrogenase 1), via the induction of NFE2-related factor 2. As2O3 caused a repression of cytochrome P450 (CYP)1B1, but the addition of 25 μM resveratrol rescued the expression of cytochrome P450 1B1 and kept it at a constant level. Therefore, 25 μM resveratrol can modulate the effects of As2O3 on enzymes involved in estrogen metabolism.

Original languageEnglish (US)
Pages (from-to)5511-5515
Number of pages5
JournalACS Omega
Volume3
Issue number5
DOIs
Publication statusPublished - May 21 2018

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ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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