Previous work indicated that transforming growth factor-β elicits proliferation-inhibitory and differentiation-like effects in the human colon carcinoma cell line MOSER. We report for the first time that the proto-oncogene c-myc is repressed in response to transforming growth factor-β in a human colon carcinoma cell line. We also describe a subline of these cells which are relatively resistant to the transforming growth factor-β-induced effects on proliferation in monolayer and in soft agarose, but which retain the ability to specifically bind transforming growth factor-β. Analysis of molecular and cellular alterations in this subline may aid in elucidating the mechanism of action of transforming growth factor-β.
|Original language||English (US)|
|Number of pages||6|
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - Jan 29 1988|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology