Modulation of apomorphine-induced climbing behavior by estradiol

Y. K. Fung, Robert W. Brueggemeier, Norman J. Uretsky

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The acute and chronic effects of estradiol benzoate were studied on apomorphine-induced climbing behavior in intact female mice. Climbing behavior was measured by determining the maximum climbing time and climbing index. Mice pretreated with estradiol benzoate (0.1 or 0.3 mg/kg, SC) for 3.5 or 24 hours prior to apomorphine administration showed no significant difference in climbing behavior when compared to corn oil-treated controls. However, mice pretreated with estradiol benzoate (0.1 mg/kg, SC) for 3 consecutive days showed an attenuation in apomorphine-induced climbing at 24 or 72 hours after the last steroid injection. This study shows that the mouse climbing behavioral model provides a simple and quantitative procedure for studying the antidopaminergic effects of estrogen.

Original languageEnglish (US)
Pages (from-to)139-141
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume24
Issue number1
DOIs
StatePublished - Jan 1986

Fingerprint

Apomorphine
Estradiol
Modulation
Corn Oil
Estrogens
Steroids
Injections
estradiol 3-benzoate

Keywords

  • Climbing behavior
  • Dopamine
  • Estradiol

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Modulation of apomorphine-induced climbing behavior by estradiol. / Fung, Y. K.; Brueggemeier, Robert W.; Uretsky, Norman J.

In: Pharmacology, Biochemistry and Behavior, Vol. 24, No. 1, 01.1986, p. 139-141.

Research output: Contribution to journalArticle

Fung, Y. K. ; Brueggemeier, Robert W. ; Uretsky, Norman J. / Modulation of apomorphine-induced climbing behavior by estradiol. In: Pharmacology, Biochemistry and Behavior. 1986 ; Vol. 24, No. 1. pp. 139-141.
@article{2068a9a2bc6247c8b6ab97593e192302,
title = "Modulation of apomorphine-induced climbing behavior by estradiol",
abstract = "The acute and chronic effects of estradiol benzoate were studied on apomorphine-induced climbing behavior in intact female mice. Climbing behavior was measured by determining the maximum climbing time and climbing index. Mice pretreated with estradiol benzoate (0.1 or 0.3 mg/kg, SC) for 3.5 or 24 hours prior to apomorphine administration showed no significant difference in climbing behavior when compared to corn oil-treated controls. However, mice pretreated with estradiol benzoate (0.1 mg/kg, SC) for 3 consecutive days showed an attenuation in apomorphine-induced climbing at 24 or 72 hours after the last steroid injection. This study shows that the mouse climbing behavioral model provides a simple and quantitative procedure for studying the antidopaminergic effects of estrogen.",
keywords = "Climbing behavior, Dopamine, Estradiol",
author = "Fung, {Y. K.} and Brueggemeier, {Robert W.} and Uretsky, {Norman J.}",
year = "1986",
month = "1",
doi = "10.1016/0091-3057(86)90057-2",
language = "English (US)",
volume = "24",
pages = "139--141",
journal = "Pharmacology Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Modulation of apomorphine-induced climbing behavior by estradiol

AU - Fung, Y. K.

AU - Brueggemeier, Robert W.

AU - Uretsky, Norman J.

PY - 1986/1

Y1 - 1986/1

N2 - The acute and chronic effects of estradiol benzoate were studied on apomorphine-induced climbing behavior in intact female mice. Climbing behavior was measured by determining the maximum climbing time and climbing index. Mice pretreated with estradiol benzoate (0.1 or 0.3 mg/kg, SC) for 3.5 or 24 hours prior to apomorphine administration showed no significant difference in climbing behavior when compared to corn oil-treated controls. However, mice pretreated with estradiol benzoate (0.1 mg/kg, SC) for 3 consecutive days showed an attenuation in apomorphine-induced climbing at 24 or 72 hours after the last steroid injection. This study shows that the mouse climbing behavioral model provides a simple and quantitative procedure for studying the antidopaminergic effects of estrogen.

AB - The acute and chronic effects of estradiol benzoate were studied on apomorphine-induced climbing behavior in intact female mice. Climbing behavior was measured by determining the maximum climbing time and climbing index. Mice pretreated with estradiol benzoate (0.1 or 0.3 mg/kg, SC) for 3.5 or 24 hours prior to apomorphine administration showed no significant difference in climbing behavior when compared to corn oil-treated controls. However, mice pretreated with estradiol benzoate (0.1 mg/kg, SC) for 3 consecutive days showed an attenuation in apomorphine-induced climbing at 24 or 72 hours after the last steroid injection. This study shows that the mouse climbing behavioral model provides a simple and quantitative procedure for studying the antidopaminergic effects of estrogen.

KW - Climbing behavior

KW - Dopamine

KW - Estradiol

UR - http://www.scopus.com/inward/record.url?scp=0022653810&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022653810&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(86)90057-2

DO - 10.1016/0091-3057(86)90057-2

M3 - Article

C2 - 3945658

AN - SCOPUS:0022653810

VL - 24

SP - 139

EP - 141

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 1

ER -