Modeling the tumor microenvironment using chitosan-alginate scaffolds to control the stem-like state of glioblastoma cells

Forrest M. Kievit, Kui Wang, Ariane E. Erickson, Sheeny K. Lan Levengood, Richard G. Ellenbogen, Miqin Zhang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Better prediction of in vivo drug efficacy using in vitro models should greatly improve in vivo success. Here we utilize 3D highly porous chitosan-alginate complex scaffolds to probe how various components of the glioblastoma microenvironment including extracellular matrix and stromal cells affect tumor cell stem-like state.

Original languageEnglish (US)
Pages (from-to)610-613
Number of pages4
JournalBiomaterials Science
Volume4
Issue number4
DOIs
StatePublished - Apr 2016

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Alginate
Chitosan
Stem cells
Scaffolds
Tumors
Pharmaceutical Preparations
alginic acid

ASJC Scopus subject areas

  • Biomedical Engineering
  • Materials Science(all)

Cite this

Modeling the tumor microenvironment using chitosan-alginate scaffolds to control the stem-like state of glioblastoma cells. / Kievit, Forrest M.; Wang, Kui; Erickson, Ariane E.; Lan Levengood, Sheeny K.; Ellenbogen, Richard G.; Zhang, Miqin.

In: Biomaterials Science, Vol. 4, No. 4, 04.2016, p. 610-613.

Research output: Contribution to journalArticle

Kievit, Forrest M. ; Wang, Kui ; Erickson, Ariane E. ; Lan Levengood, Sheeny K. ; Ellenbogen, Richard G. ; Zhang, Miqin. / Modeling the tumor microenvironment using chitosan-alginate scaffolds to control the stem-like state of glioblastoma cells. In: Biomaterials Science. 2016 ; Vol. 4, No. 4. pp. 610-613.
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