Modeling the Effects of Multiple Myeloma on Kidney Function

Julia C. Walk, Bruce P. Ayati, Sarah A Holstein

Research output: Contribution to journalArticle

Abstract

Multiple myeloma (MM), a plasma cell cancer, is associated with many health challenges, including damage to the kidney by tubulointerstitial fibrosis. We develop a mathematical model which captures the qualitative behavior of the cell and protein populations involved. Specifically, we model the interaction between cells in the proximal tubule of the kidney, free light chains, renal fibroblasts, and myeloma cells. We analyze the model for steady-state solutions to find a mathematically and biologically relevant stable steady-state solution. This foundational model provides a representation of dynamics between key populations in tubulointerstitial fibrosis that demonstrates how these populations interact to affect patient prognosis in patients with MM and renal impairment.

Original languageEnglish (US)
Article number1726
JournalScientific Reports
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2019

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Multiple Myeloma
Kidney
Fibrosis
Population
Proximal Kidney Tubule
Plasma Cells
Cell Communication
Theoretical Models
Fibroblasts
Light
Health
Neoplasms
Proteins

ASJC Scopus subject areas

  • General

Cite this

Modeling the Effects of Multiple Myeloma on Kidney Function. / Walk, Julia C.; Ayati, Bruce P.; Holstein, Sarah A.

In: Scientific Reports, Vol. 9, No. 1, 1726, 01.12.2019.

Research output: Contribution to journalArticle

Walk, Julia C. ; Ayati, Bruce P. ; Holstein, Sarah A. / Modeling the Effects of Multiple Myeloma on Kidney Function. In: Scientific Reports. 2019 ; Vol. 9, No. 1.
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