Model systems for assessing cognitive function: Implications for HIV-1 infection and drugs of abuse

W. E. Zink, J. Boyle, Y. Persidsky, Huangui Xiong, Howard Eliot Gendelman

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Memory deficits are common among drug abusers and in those with chronic neurodegenerative disorders. Currently, the mechanisms through which diverse neurophysiologic processes alter memory are not known. This review describes the current systems and rationale for studying memory formation, consolidation, and recall. Special attention is given to physiologic (hippocampal long-term potentiation) and behavioral animal models. The principles and methods described can be applied to studies of diverse clinical disorders.

Original languageEnglish (US)
Pages (from-to)7-27
Number of pages21
JournalAdvances in experimental medicine and biology
Volume493
StatePublished - Dec 1 2001

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Long-Term Potentiation
Memory Disorders
Street Drugs
Drug Users
Neurodegenerative Diseases
Cognition
HIV Infections
HIV-1
Animal Models
Data storage equipment
Consolidation
Animals
Pharmaceutical Preparations
Memory Consolidation
Clinical Studies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Model systems for assessing cognitive function : Implications for HIV-1 infection and drugs of abuse. / Zink, W. E.; Boyle, J.; Persidsky, Y.; Xiong, Huangui; Gendelman, Howard Eliot.

In: Advances in experimental medicine and biology, Vol. 493, 01.12.2001, p. 7-27.

Research output: Contribution to journalArticle

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