MMP-9 signaling in the left ventricle following myocardial infarction

Rugmani Padmanabhan Iyer, Mira Jung, Merry L Lindsey

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

Following myocardial infarction (MI), the left ventricle (LV) undergoes a series of cardiac wound healing responses that involve both the stimulation of robust inflammation to clear necrotic myocytes and tissue debris and the induction of extracellular matrix (ECM) protein synthesis to generate an infarct scar. The collective changes in myocardial structure and function are termed LV remodeling, and matrix metalloproteinase-9 (MMP-9) is a key instigator of post-MI LV remodeling. Through direct molecular effects on ECM and inflammatory protein turnover as well as indirect effects on major cell types that coordinate cardiac wound healing, namely the infiltrating leukocytes and the cardiac fibroblasts, MMP-9 coordinates multiple aspects of LV remodeling. In this review, we will discuss recent research that has expanded our understanding of post-MI LV remodeling, including recent proteomic advances focused on the ECM compartment to provide novel functional and translational insights. This overview will summarize how our understanding of MMP-9 has evolved over the last decade and will provide insight into future directions that will drive our understanding of MMP-9-directed cardiac ECM turnover in the post-MI LV.

Original languageEnglish (US)
Pages (from-to)H190-H198
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume311
Issue number1
DOIs
StatePublished - Jul 1 2016
Externally publishedYes

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Ventricular Remodeling
Matrix Metalloproteinase 9
Heart Ventricles
Myocardial Infarction
Extracellular Matrix Proteins
Wound Healing
Extracellular Matrix
Proteomics
Muscle Cells
Cicatrix
Leukocytes
Fibroblasts
Inflammation
Research

Keywords

  • Extracellular matrix
  • Matrix metalloproteinases-9
  • Proteomics
  • Signaling
  • Transcription factors

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

MMP-9 signaling in the left ventricle following myocardial infarction. / Iyer, Rugmani Padmanabhan; Jung, Mira; Lindsey, Merry L.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 311, No. 1, 01.07.2016, p. H190-H198.

Research output: Contribution to journalReview article

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