Mitosin/CENP-F in mitosis, transcriptional control, and differentiation

Li Ma, Xiangshan Zhao, Xueliang Zhu

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

Mitosin/CENP-F is a large nuclear/kinetochore protein containing multiple leucine zipper motifs potentially for protein interactions. Its expression levels and subcellular localization patterns are regulated in a cell cycle-dependent manner. Recently, accumulating lines of evidence have suggested it a multifunctional protein involved in mitotic control, microtubule dynamics, transcriptional regulation, and muscle cell differentiation. Consistently, it is shown to interact directly with a variety of proteins including CENP-E, NudE/Nudel, ATF4, and Rb. Here we review the current progress and discuss possible mechanisms through which mitosin may function.

Original languageEnglish (US)
Pages (from-to)205-213
Number of pages9
JournalJournal of Biomedical Science
Volume13
Issue number2
DOIs
StatePublished - Mar 1 2006

Fingerprint

Mitosis
Cells
Protein Interaction Domains and Motifs
Kinetochores
Leucine Zippers
Nuclear Proteins
Microtubules
Muscle Cells
Muscle
Cell Differentiation
Cell Cycle
Proteins
centromere protein F
centromere protein E

Keywords

  • Differentiation
  • Kinetochore
  • Mitosis
  • Transcription

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

Cite this

Mitosin/CENP-F in mitosis, transcriptional control, and differentiation. / Ma, Li; Zhao, Xiangshan; Zhu, Xueliang.

In: Journal of Biomedical Science, Vol. 13, No. 2, 01.03.2006, p. 205-213.

Research output: Contribution to journalReview article

Ma, Li ; Zhao, Xiangshan ; Zhu, Xueliang. / Mitosin/CENP-F in mitosis, transcriptional control, and differentiation. In: Journal of Biomedical Science. 2006 ; Vol. 13, No. 2. pp. 205-213.
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