MitoProteome

Mitochondrial protein sequence database and annotation system

Dawn Cotter, Purnima Guda, Eoin Fahy, Shankar Subramaniam

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

MitoProteome is an object-relational mitochondrial protein sequence database and annotation system. The initial release contains 847 human mitochondrial protein sequences, derived from public sequence databases and mass spectrometric analysis of highly purified human heart mitochondria. Each sequence is manually annotated with primary function, subfunction and subcellular location, and extensively annotated in an automated process with data extracted from external databases, including gene information from LocusLink and Ensembl; disease information from OMIM; protein-protein interaction data from MINT and DIP; functional domain information from Pfam; protein fingerprints from PRINTS; protein family and family-specific signatures from InterPro; structure data from PDB; mutation data from PMD; BLAST homology data from NCBI NR; and proteins found to be related based on LocusLink and SWISS-PROT references and sequence and taxonomy data. By highly automating the processes of maintaining the MitoProteome Protein List and extracting relevant data from external databases, we are able to present a dynamic database, updated frequently to reflect changes in public resources. The MitoProteome database is publicly available at http://www.mitoproteome.org/. Users may browse and search MitoProteome, and access a complete compilation of data relevant to each protein of interest, cross-linked to external databases.

Original languageEnglish (US)
JournalNucleic acids research
Volume32
Issue numberDATABASE ISS.
StatePublished - Jan 1 2004

Fingerprint

Molecular Sequence Annotation
Protein Databases
Mitochondrial Proteins
Databases
Proteins
Genetic Databases
Heart Mitochondria
Peptide Mapping
Mutation
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

MitoProteome : Mitochondrial protein sequence database and annotation system. / Cotter, Dawn; Guda, Purnima; Fahy, Eoin; Subramaniam, Shankar.

In: Nucleic acids research, Vol. 32, No. DATABASE ISS., 01.01.2004.

Research output: Contribution to journalArticle

Cotter, D, Guda, P, Fahy, E & Subramaniam, S 2004, 'MitoProteome: Mitochondrial protein sequence database and annotation system', Nucleic acids research, vol. 32, no. DATABASE ISS..
Cotter, Dawn ; Guda, Purnima ; Fahy, Eoin ; Subramaniam, Shankar. / MitoProteome : Mitochondrial protein sequence database and annotation system. In: Nucleic acids research. 2004 ; Vol. 32, No. DATABASE ISS.
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