Minocycline pigmentation of heart valves

Sara Sant'Ambrogio, John Connelly, Dominick Dimaio

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Minocycline, a derivative of tetracycline, is a broad spectrum antibiotic used in the treatment of gram-positive and gram-negative infections. Benitz et al. (1) were the first to report black discoloration of the thyroid gland in rats, dogs, and monkeys given minocycline. Since that time, there have been numerous reports in the literature describing minocycline related black pigmentation of the skin, thyroid gland, and other sites. We report an unusual case of minocycline induced pigmentation of the cardiac valves and coronary vessels. The pigment stained with Fontana-Masson and was reduced with bleaching. The exact nature of the pigment is unclear; however, various theories have been advocated. Ochronosis is another cause of black pigmentation of the heart valves; the clinical history should allow distinction between the two.

Original languageEnglish (US)
Pages (from-to)329-332
Number of pages4
JournalCardiovascular Pathology
Volume8
Issue number6
DOIs
StatePublished - Nov 1 1999

Fingerprint

Minocycline
Heart Valves
Pigmentation
Thyroid Gland
Ochronosis
Skin Pigmentation
Tetracycline
Haplorhini
Coronary Vessels
Dogs
Anti-Bacterial Agents
Infection

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Minocycline pigmentation of heart valves. / Sant'Ambrogio, Sara; Connelly, John; Dimaio, Dominick.

In: Cardiovascular Pathology, Vol. 8, No. 6, 01.11.1999, p. 329-332.

Research output: Contribution to journalArticle

Sant'Ambrogio, Sara ; Connelly, John ; Dimaio, Dominick. / Minocycline pigmentation of heart valves. In: Cardiovascular Pathology. 1999 ; Vol. 8, No. 6. pp. 329-332.
@article{8ae0ff5234cd449488887e5bd18cba4d,
title = "Minocycline pigmentation of heart valves",
abstract = "Minocycline, a derivative of tetracycline, is a broad spectrum antibiotic used in the treatment of gram-positive and gram-negative infections. Benitz et al. (1) were the first to report black discoloration of the thyroid gland in rats, dogs, and monkeys given minocycline. Since that time, there have been numerous reports in the literature describing minocycline related black pigmentation of the skin, thyroid gland, and other sites. We report an unusual case of minocycline induced pigmentation of the cardiac valves and coronary vessels. The pigment stained with Fontana-Masson and was reduced with bleaching. The exact nature of the pigment is unclear; however, various theories have been advocated. Ochronosis is another cause of black pigmentation of the heart valves; the clinical history should allow distinction between the two.",
author = "Sara Sant'Ambrogio and John Connelly and Dominick Dimaio",
year = "1999",
month = "11",
day = "1",
doi = "10.1016/S1054-8807(99)00023-X",
language = "English (US)",
volume = "8",
pages = "329--332",
journal = "Cardiovascular Pathology",
issn = "1054-8807",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Minocycline pigmentation of heart valves

AU - Sant'Ambrogio, Sara

AU - Connelly, John

AU - Dimaio, Dominick

PY - 1999/11/1

Y1 - 1999/11/1

N2 - Minocycline, a derivative of tetracycline, is a broad spectrum antibiotic used in the treatment of gram-positive and gram-negative infections. Benitz et al. (1) were the first to report black discoloration of the thyroid gland in rats, dogs, and monkeys given minocycline. Since that time, there have been numerous reports in the literature describing minocycline related black pigmentation of the skin, thyroid gland, and other sites. We report an unusual case of minocycline induced pigmentation of the cardiac valves and coronary vessels. The pigment stained with Fontana-Masson and was reduced with bleaching. The exact nature of the pigment is unclear; however, various theories have been advocated. Ochronosis is another cause of black pigmentation of the heart valves; the clinical history should allow distinction between the two.

AB - Minocycline, a derivative of tetracycline, is a broad spectrum antibiotic used in the treatment of gram-positive and gram-negative infections. Benitz et al. (1) were the first to report black discoloration of the thyroid gland in rats, dogs, and monkeys given minocycline. Since that time, there have been numerous reports in the literature describing minocycline related black pigmentation of the skin, thyroid gland, and other sites. We report an unusual case of minocycline induced pigmentation of the cardiac valves and coronary vessels. The pigment stained with Fontana-Masson and was reduced with bleaching. The exact nature of the pigment is unclear; however, various theories have been advocated. Ochronosis is another cause of black pigmentation of the heart valves; the clinical history should allow distinction between the two.

UR - http://www.scopus.com/inward/record.url?scp=0032739858&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032739858&partnerID=8YFLogxK

U2 - 10.1016/S1054-8807(99)00023-X

DO - 10.1016/S1054-8807(99)00023-X

M3 - Article

C2 - 10615019

AN - SCOPUS:0032739858

VL - 8

SP - 329

EP - 332

JO - Cardiovascular Pathology

JF - Cardiovascular Pathology

SN - 1054-8807

IS - 6

ER -