Mild traumatic brain injury with social defeat stress alters anxiety, Contextual fear extinction, and limbic monoamines in adult rats

Daniel R. Davies, Dawne Olson, Danielle L. Meyer, Jamie L. Scholl, Michael J. Watt, Pasquale Manzerra, Kenneth J. Renner, Gina L. Forster

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Mild traumatic brain injury (mTBI) produces symptoms similar to those typifying posttraumatic stress disorder (PTSD) in humans. We sought to determine whether a rodent model of stress concurrent with mTBI produces characteristics of PTSD such as impaired contextual fear extinction, while also examining concurrent alterations to limbic monoamine activity in brain regions relevant to fear and anxiety states. Male rats were exposed to social stress or control conditions immediately prior to mTBI induction, and 6 days later were tested either for anxiety-like behavior using the elevated plus maze (EPM), or for contextual fear conditioning and extinction. Brains were collected 24 h after EPM testing, and tissue from various limbic regions analyzed for content of monoamines, their precursors and metabolites using HPLC with electrochemical detection. Either social defeat or mTBI alone decreased time spent in open arms of the EPM, indicating greater anxiety-like behavior. However, this effect was enhanced by the combination of treatments. Further, rats exposed to both social defeat and mTBI exhibited greater freezing within extinction sessions compared to all other groups, suggesting impaired contextual fear extinction. Social defeat combined with mTBI also had greater effects on limbic monoamines than either insult alone, particularly with respect to serotonergic effects associated with anxiety and fear learning. The results suggest social stress concurrent with mTBI produces provides a relevant animal model for studying the prevention and treatment of post-concussive psychobiological outcomes.

Original languageEnglish (US)
Article number71
JournalFrontiers in Behavioral Neuroscience
Volume10
Issue numberAPRIL
DOIs
StatePublished - Apr 19 2016

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Brain Concussion
Fear
Anxiety
Post-Traumatic Stress Disorders
Brain
Psychological Extinction
Freezing
Rodentia
Animal Models
High Pressure Liquid Chromatography
Learning

Keywords

  • Anxiety
  • Fear conditioning
  • Mild traumatic brain injury
  • Monoamine
  • Posttraumatic stress disorder
  • Social stress

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Mild traumatic brain injury with social defeat stress alters anxiety, Contextual fear extinction, and limbic monoamines in adult rats. / Davies, Daniel R.; Olson, Dawne; Meyer, Danielle L.; Scholl, Jamie L.; Watt, Michael J.; Manzerra, Pasquale; Renner, Kenneth J.; Forster, Gina L.

In: Frontiers in Behavioral Neuroscience, Vol. 10, No. APRIL, 71, 19.04.2016.

Research output: Contribution to journalArticle

Davies, Daniel R. ; Olson, Dawne ; Meyer, Danielle L. ; Scholl, Jamie L. ; Watt, Michael J. ; Manzerra, Pasquale ; Renner, Kenneth J. ; Forster, Gina L. / Mild traumatic brain injury with social defeat stress alters anxiety, Contextual fear extinction, and limbic monoamines in adult rats. In: Frontiers in Behavioral Neuroscience. 2016 ; Vol. 10, No. APRIL.
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