MicroRNomics of diabetic cardiomyopathy

Paras Kumar Mishra, Suresh C. Tyagi

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

MicroRNAs (miRNAs) are a novel class of noncoding, conserved, tiny (19-24 nt) RNAs that regulate gene expression either by RNA interference (RNAi), where they target 3'-UTR and degrade mRNA or repress translation, or by RNA activation (RNAa), where they target promoter elements at 5'-UTR and induce gene transcription. They have emerged as a therapeutic target for diabetes and cardiovascular diseases because each miRNA has several targets that allows it to make a layer of regulatory network. Diabetes is recognized as a multifactorial metabolic disease that increases the chances of heart failure and exacerbates mortality. MiRNAs regulates insulin production, beta-cell differentiation, cardiac hypertrophy, fi brosis, and rhythm, and thereby plays a crucial role in cardiac remodeling in diabetes. Differential expression of circulatory miRNAs has potential as a biomarker for heart failure in diabetes. It is documented that miRNAs regulate infl ammation, epigenetic modifi cations, and autophagy and are altered by matrix metalloproteinase 9, homocysteine, and exercise, which are associated with diabetic cardiomyopathy. This chapter embodies the differentially expressed miRNAs in diabetic hearts, their plausible causes of deregulation, and the therapeutic potential of miRNAs in ameliorating diabetic cardiomyopathy.

Original languageEnglish (US)
Title of host publicationDiabetic Cardiomyopathy
Subtitle of host publicationBiochemical and Molecular Mechanisms
PublisherSpringer New York
Pages179-187
Number of pages9
ISBN (Electronic)9781461493174
ISBN (Print)9781461493167
DOIs
Publication statusPublished - Jan 1 2014

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Keywords

  • Diabetes
  • Epigenetics
  • Exercise
  • Heart failure
  • Homocysteine
  • MMP
  • Therapy
  • miRNA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Mishra, P. K., & Tyagi, S. C. (2014). MicroRNomics of diabetic cardiomyopathy. In Diabetic Cardiomyopathy: Biochemical and Molecular Mechanisms (pp. 179-187). Springer New York. https://doi.org/10.1007/978-1-4614-9317-4_10