MicroRNAs involved in tumor suppressor and oncogene pathways

Implications for hepatobiliary neoplasia

Research output: Contribution to journalReview article

88 Citations (Scopus)

Abstract

MicroRNAs are a class of small regulatory RNAs that function to modulate protein expression. This control allows for fine-tuning of the cellular phenotype, including regulation of proliferation, cell signaling, and apoptosis; not surprisingly, microRNAs contribute to liver cancer biology. Recent investigations in human liver cancers and tumor-derived cell lines have demonstrated decreased or increased expression of particular microRNAs in hepatobiliary cancer cells. Based on predicted and validated protein targets as well as functional consequences of altered expression, microRNAs with decreased expression in liver tumor cells may normally aid in limiting neoplastic transformation. Conversely, selected microRNAs that are up-regulated in liver tumor cells can promote malignant features, contributing to carcinogenesis. In addition, microRNAs themselves are subject to regulated expression, including regulation by tumor suppressor and oncogene pathways. This review will focus on the expression and function of cancer-related microRNAs, including their intimate involvement in tumor suppressor and oncogene signaling networks relevant to hepatobiliary neoplasia.

Original languageEnglish (US)
Pages (from-to)630-637
Number of pages8
JournalHepatology
Volume50
Issue number2
DOIs
StatePublished - Nov 26 2009

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MicroRNAs
Oncogenes
Neoplasms
Liver Neoplasms
Liver
Tumor Cell Line
Carcinogenesis
Proteins
Cell Proliferation
RNA
Apoptosis
Phenotype

ASJC Scopus subject areas

  • Hepatology

Cite this

MicroRNAs involved in tumor suppressor and oncogene pathways : Implications for hepatobiliary neoplasia. / Mott, Justin L.

In: Hepatology, Vol. 50, No. 2, 26.11.2009, p. 630-637.

Research output: Contribution to journalReview article

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