Abstract
Advances in understanding the biology of tumour progression and metastasis have clearly highlighted the importance of aberrant tumour metabolism, which supports not only the energy requirements but also the enormous biosynthetic needs of tumour cells. Such metabolic alterations modulate glucose, amino acid and fatty-acid-dependent metabolite biosynthesis and energy production. Although much progress has been made in understanding the somatic mutations and expression genomics behind these alterations, the regulation of these processes by microRNAs (miRNAs) is only just beginning to be appreciated. This Review focuses on the miRNAs that are potential regulators of the expression of genes whose protein products either directly regulate metabolic machinery or serve as master regulators, indirectly modulating the expression of metabolic enzymes. We focus particularly on miRNAs in pancreatic cancer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 334-344 |
| Number of pages | 11 |
| Journal | Nature Reviews Gastroenterology and Hepatology |
| Volume | 9 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2012 |
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ASJC Scopus subject areas
- Hepatology
- Gastroenterology
Cite this
MicroRNAs in pancreatic cancer metabolism. / Singh, Pankaj; Brand, Randall E.; Mehla, Kamiya.
In: Nature Reviews Gastroenterology and Hepatology, Vol. 9, No. 6, 01.06.2012, p. 334-344.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - MicroRNAs in pancreatic cancer metabolism
AU - Singh, Pankaj
AU - Brand, Randall E.
AU - Mehla, Kamiya
PY - 2012/6/1
Y1 - 2012/6/1
N2 - Advances in understanding the biology of tumour progression and metastasis have clearly highlighted the importance of aberrant tumour metabolism, which supports not only the energy requirements but also the enormous biosynthetic needs of tumour cells. Such metabolic alterations modulate glucose, amino acid and fatty-acid-dependent metabolite biosynthesis and energy production. Although much progress has been made in understanding the somatic mutations and expression genomics behind these alterations, the regulation of these processes by microRNAs (miRNAs) is only just beginning to be appreciated. This Review focuses on the miRNAs that are potential regulators of the expression of genes whose protein products either directly regulate metabolic machinery or serve as master regulators, indirectly modulating the expression of metabolic enzymes. We focus particularly on miRNAs in pancreatic cancer.
AB - Advances in understanding the biology of tumour progression and metastasis have clearly highlighted the importance of aberrant tumour metabolism, which supports not only the energy requirements but also the enormous biosynthetic needs of tumour cells. Such metabolic alterations modulate glucose, amino acid and fatty-acid-dependent metabolite biosynthesis and energy production. Although much progress has been made in understanding the somatic mutations and expression genomics behind these alterations, the regulation of these processes by microRNAs (miRNAs) is only just beginning to be appreciated. This Review focuses on the miRNAs that are potential regulators of the expression of genes whose protein products either directly regulate metabolic machinery or serve as master regulators, indirectly modulating the expression of metabolic enzymes. We focus particularly on miRNAs in pancreatic cancer.
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UR - http://www.scopus.com/inward/citedby.url?scp=84861973911&partnerID=8YFLogxK
U2 - 10.1038/nrgastro.2012.63
DO - 10.1038/nrgastro.2012.63
M3 - Review article
VL - 9
SP - 334
EP - 344
JO - Nature Reviews Gastroenterology and Hepatology
JF - Nature Reviews Gastroenterology and Hepatology
SN - 1759-5045
IS - 6
ER -