MicroRNAs and Noncoding RNAs in Hepatic Lipid and Lipoprotein Metabolism: Potential Therapeutic Targets of Metabolic Disorders

Neetu Sud, Jennifer Taher, Qiaozhu Su

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Preclinical Research Noncoding RNAs and microRNAs (miRNAs) represent an important class of regulatory molecules that modulate gene expression. The role of miRNAs in diverse cellular processes such as cancer, apoptosis, cell differentiation, cardiac remodeling, and inflammation has been intensively explored. Recent studies further demonstrated the important roles of miRNAs and noncoding RNAs in modulating a broad spectrum of genes involved in lipid synthesis and metabolic pathways. This overview focuses on the role of miRNAs in hepatic lipid and lipoprotein metabolism and their potential as therapeutic targets for metabolic syndrome. This includes recent advances made in the understanding of their target pathways and the clinical development of miRNAs in lipid metabolic disorders. Drug Dev Res 76: 318-327, 2015.

Original languageEnglish (US)
Pages (from-to)318-327
Number of pages10
JournalDrug Development Research
Volume76
Issue number6
DOIs
StatePublished - Sep 1 2015

Fingerprint

Untranslated RNA
MicroRNAs
Lipid Metabolism
Lipoproteins
Liver
Lipids
Therapeutics
Critical Pathways
Metabolic Networks and Pathways
Cell Differentiation
Apoptosis
Inflammation
Gene Expression
Research
Pharmaceutical Preparations
Genes
Neoplasms

Keywords

  • drug-development
  • dyslipidemia
  • metabolic syndrome
  • microRNAs
  • noncoding RNAs

ASJC Scopus subject areas

  • Drug Discovery

Cite this

MicroRNAs and Noncoding RNAs in Hepatic Lipid and Lipoprotein Metabolism : Potential Therapeutic Targets of Metabolic Disorders. / Sud, Neetu; Taher, Jennifer; Su, Qiaozhu.

In: Drug Development Research, Vol. 76, No. 6, 01.09.2015, p. 318-327.

Research output: Contribution to journalReview article

@article{2a78d18d46ff404a975e5ed8fefeb0f5,
title = "MicroRNAs and Noncoding RNAs in Hepatic Lipid and Lipoprotein Metabolism: Potential Therapeutic Targets of Metabolic Disorders",
abstract = "Preclinical Research Noncoding RNAs and microRNAs (miRNAs) represent an important class of regulatory molecules that modulate gene expression. The role of miRNAs in diverse cellular processes such as cancer, apoptosis, cell differentiation, cardiac remodeling, and inflammation has been intensively explored. Recent studies further demonstrated the important roles of miRNAs and noncoding RNAs in modulating a broad spectrum of genes involved in lipid synthesis and metabolic pathways. This overview focuses on the role of miRNAs in hepatic lipid and lipoprotein metabolism and their potential as therapeutic targets for metabolic syndrome. This includes recent advances made in the understanding of their target pathways and the clinical development of miRNAs in lipid metabolic disorders. Drug Dev Res 76: 318-327, 2015.",
keywords = "drug-development, dyslipidemia, metabolic syndrome, microRNAs, noncoding RNAs",
author = "Neetu Sud and Jennifer Taher and Qiaozhu Su",
year = "2015",
month = "9",
day = "1",
doi = "10.1002/ddr.21269",
language = "English (US)",
volume = "76",
pages = "318--327",
journal = "Drug Development Research",
issn = "0272-4391",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - MicroRNAs and Noncoding RNAs in Hepatic Lipid and Lipoprotein Metabolism

T2 - Potential Therapeutic Targets of Metabolic Disorders

AU - Sud, Neetu

AU - Taher, Jennifer

AU - Su, Qiaozhu

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Preclinical Research Noncoding RNAs and microRNAs (miRNAs) represent an important class of regulatory molecules that modulate gene expression. The role of miRNAs in diverse cellular processes such as cancer, apoptosis, cell differentiation, cardiac remodeling, and inflammation has been intensively explored. Recent studies further demonstrated the important roles of miRNAs and noncoding RNAs in modulating a broad spectrum of genes involved in lipid synthesis and metabolic pathways. This overview focuses on the role of miRNAs in hepatic lipid and lipoprotein metabolism and their potential as therapeutic targets for metabolic syndrome. This includes recent advances made in the understanding of their target pathways and the clinical development of miRNAs in lipid metabolic disorders. Drug Dev Res 76: 318-327, 2015.

AB - Preclinical Research Noncoding RNAs and microRNAs (miRNAs) represent an important class of regulatory molecules that modulate gene expression. The role of miRNAs in diverse cellular processes such as cancer, apoptosis, cell differentiation, cardiac remodeling, and inflammation has been intensively explored. Recent studies further demonstrated the important roles of miRNAs and noncoding RNAs in modulating a broad spectrum of genes involved in lipid synthesis and metabolic pathways. This overview focuses on the role of miRNAs in hepatic lipid and lipoprotein metabolism and their potential as therapeutic targets for metabolic syndrome. This includes recent advances made in the understanding of their target pathways and the clinical development of miRNAs in lipid metabolic disorders. Drug Dev Res 76: 318-327, 2015.

KW - drug-development

KW - dyslipidemia

KW - metabolic syndrome

KW - microRNAs

KW - noncoding RNAs

UR - http://www.scopus.com/inward/record.url?scp=84941260044&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941260044&partnerID=8YFLogxK

U2 - 10.1002/ddr.21269

DO - 10.1002/ddr.21269

M3 - Review article

C2 - 26286650

AN - SCOPUS:84941260044

VL - 76

SP - 318

EP - 327

JO - Drug Development Research

JF - Drug Development Research

SN - 0272-4391

IS - 6

ER -