MicroRNA Regulation of HDL Homeostasis

Xinghui Sun, Mark W. Feinberg

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

MicroRNAs (miRNAs) represent an important class of noncoding RNAs that play key roles in regulating the expression of genes in health and disease. Accumulating experimental, pathological, genetic, epidemiological, and clinical studies highlight a growing list of miRNAs that control lipoprotein homeostasis and high-density lipoprotein (HDL) metabolism. By "fine-tuning" the expression of genes or signaling networks, miRNAs actively modulate HDL biogenesis and function including efflux of cholesterol from the vessel wall, altering inflammatory responses, or facilitating reverse cholesterol transport. This chapter highlights emerging concepts in miRNA-mediated control of HDL homeostasis as well as some of the challenges and therapeutic opportunities in the pathogenesis of cardiovascular and metabolic diseases.

Original languageEnglish (US)
Title of host publicationThe HDL Handbook
Subtitle of host publicationBiological Functions and Clinical Implications: Third Edition
PublisherElsevier Inc.
Pages209-229
Number of pages21
ISBN (Print)9780128125137
DOIs
Publication statusPublished - Feb 22 2017

    Fingerprint

Keywords

  • ABCA1
  • Atherosclerosis
  • CETP
  • Cardiovascular
  • Cholesterol
  • HDL
  • LCAT
  • LDL
  • Liver
  • Macrophage
  • Metabolism
  • MicroRNA
  • MicroRNA therapeutics
  • Reverse cholesterol transport
  • VLDL

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sun, X., & Feinberg, M. W. (2017). MicroRNA Regulation of HDL Homeostasis. In The HDL Handbook: Biological Functions and Clinical Implications: Third Edition (pp. 209-229). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-812513-7.00010-0