### Abstract

The important purpose of the microarray gene expression data analysis is to identify significantly differentially-expressed genes between two groups of samples which are in two different experimental states. In this work, we propose to use several statistical test methods for a given microarray data set and cross-refer the results of different statistical test methods. The accuracy of different statistical methods is estimated by Receiver Operation Characteristic (ROC) technique. A new software tool, MicroMultitest, was developed. A number of statistical testing methods (such as t-test, adapted SAM method, p-value adjustments), as well as the ROC analysis technique were implemented in this software. Using the MicroMultitest one has the ability to evaluate the performance of different statistical testing methods by applying each to the same given microarray data set, optimize the cutoff values and permutation times for these statistical testing methods, and select relative reliable differentially-expressed gene set.

Original language | English (US) |
---|---|

Number of pages | 1 |

Journal | Proceedings of the Annual Hawaii International Conference on System Sciences |

State | Published - Nov 10 2005 |

Externally published | Yes |

Event | 38th Annual Hawaii International Conference on System Sciences - Big Island, HI, United States Duration: Jan 3 2005 → Jan 6 2005 |

### Fingerprint

### ASJC Scopus subject areas

- Engineering(all)

### Cite this

*Proceedings of the Annual Hawaii International Conference on System Sciences*.

**MicroMultitest : Ranking differentially-expressed genes in microarray data.** / Xiao, Li; Cao, Linfeng; Iqbal, Javeed; Zhou, Guimei; Chan, Wing C.; Sherman, Simon.

Research output: Contribution to journal › Conference article

*Proceedings of the Annual Hawaii International Conference on System Sciences*.

}

TY - JOUR

T1 - MicroMultitest

T2 - Ranking differentially-expressed genes in microarray data

AU - Xiao, Li

AU - Cao, Linfeng

AU - Iqbal, Javeed

AU - Zhou, Guimei

AU - Chan, Wing C.

AU - Sherman, Simon

PY - 2005/11/10

Y1 - 2005/11/10

N2 - The important purpose of the microarray gene expression data analysis is to identify significantly differentially-expressed genes between two groups of samples which are in two different experimental states. In this work, we propose to use several statistical test methods for a given microarray data set and cross-refer the results of different statistical test methods. The accuracy of different statistical methods is estimated by Receiver Operation Characteristic (ROC) technique. A new software tool, MicroMultitest, was developed. A number of statistical testing methods (such as t-test, adapted SAM method, p-value adjustments), as well as the ROC analysis technique were implemented in this software. Using the MicroMultitest one has the ability to evaluate the performance of different statistical testing methods by applying each to the same given microarray data set, optimize the cutoff values and permutation times for these statistical testing methods, and select relative reliable differentially-expressed gene set.

AB - The important purpose of the microarray gene expression data analysis is to identify significantly differentially-expressed genes between two groups of samples which are in two different experimental states. In this work, we propose to use several statistical test methods for a given microarray data set and cross-refer the results of different statistical test methods. The accuracy of different statistical methods is estimated by Receiver Operation Characteristic (ROC) technique. A new software tool, MicroMultitest, was developed. A number of statistical testing methods (such as t-test, adapted SAM method, p-value adjustments), as well as the ROC analysis technique were implemented in this software. Using the MicroMultitest one has the ability to evaluate the performance of different statistical testing methods by applying each to the same given microarray data set, optimize the cutoff values and permutation times for these statistical testing methods, and select relative reliable differentially-expressed gene set.

UR - http://www.scopus.com/inward/record.url?scp=27544456118&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27544456118&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:27544456118

JO - Proceedings of the Annual Hawaii International Conference on System Sciences

JF - Proceedings of the Annual Hawaii International Conference on System Sciences

SN - 1530-1605

ER -