Microbubble cavitation imaging

Francois Vignon, William Shi, Jeffry E. Powers, E. Carr Everbach, Jinjin Liu, Shunji Gao, Feng Xie, Thomas Richard Porter

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Ultrasound cavitation of microbubble contrast agents has a potential for therapeutic applications such as sonothrombolysis (STL) in acute ischemic stroke. For safety, efficacy, and reproducibility of treatment, it is critical to evaluate the cavitation state (moderate oscillations, stable cavitation, and inertial cavitation) and activity level in and around a treatment area. Acoustic passive cavitation detectors (PCDs) have been used to this end but do not provide spatial information. This paper presents a prototype of a 2-D cavitation imager capable of producing images of the dominant cavitation state and activity level in a region of interest. Similar to PCDs, the cavitation imaging described here is based on the spectral analysis of the acoustic signal radiated by the cavitating microbubbles: ultraharmonics of the excitation frequency indicate stable cavitation, whereas elevated noise bands indicate inertial cavitation; the absence of both indicates moderate oscillations. The prototype system is a modified commercially available ultrasound scanner with a sector imaging probe. The lateral resolution of the system is 1.5 mm at a focal depth of 3 cm, and the axial resolution is 3 cm for a therapy pulse length of 20 ¿s. The maximum frame rate of the prototype is 2 Hz. The system has been used for assessing and mapping the relative importance of the different cavitation states of a microbubble contrast agent. In vitro (tissue-mimicking flow phantom) and in vivo (heart, liver, and brain of two swine) results for cavitation states and their changes as a function of acoustic amplitude are presented.

Original languageEnglish (US)
Article number6489801
Pages (from-to)661-670
Number of pages10
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Volume60
Issue number4
DOIs
StatePublished - Apr 10 2013

Fingerprint

cavitation flow
Cavitation
Imaging techniques
Acoustics
prototypes
acoustics
Ultrasonics
stable oscillations
Detectors
swine
detectors
strokes
liver
Image sensors
Liver
Spectrum analysis
scanners
brain
spectrum analysis
therapy

ASJC Scopus subject areas

  • Instrumentation
  • Acoustics and Ultrasonics
  • Electrical and Electronic Engineering

Cite this

Vignon, F., Shi, W., Powers, J. E., Everbach, E. C., Liu, J., Gao, S., ... Porter, T. R. (2013). Microbubble cavitation imaging. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 60(4), 661-670. [6489801]. https://doi.org/10.1109/TUFFC.2013.2615

Microbubble cavitation imaging. / Vignon, Francois; Shi, William; Powers, Jeffry E.; Everbach, E. Carr; Liu, Jinjin; Gao, Shunji; Xie, Feng; Porter, Thomas Richard.

In: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Vol. 60, No. 4, 6489801, 10.04.2013, p. 661-670.

Research output: Contribution to journalArticle

Vignon, F, Shi, W, Powers, JE, Everbach, EC, Liu, J, Gao, S, Xie, F & Porter, TR 2013, 'Microbubble cavitation imaging', IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 60, no. 4, 6489801, pp. 661-670. https://doi.org/10.1109/TUFFC.2013.2615
Vignon F, Shi W, Powers JE, Everbach EC, Liu J, Gao S et al. Microbubble cavitation imaging. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 2013 Apr 10;60(4):661-670. 6489801. https://doi.org/10.1109/TUFFC.2013.2615
Vignon, Francois ; Shi, William ; Powers, Jeffry E. ; Everbach, E. Carr ; Liu, Jinjin ; Gao, Shunji ; Xie, Feng ; Porter, Thomas Richard. / Microbubble cavitation imaging. In: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 2013 ; Vol. 60, No. 4. pp. 661-670.
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