Microbial mutagenicity of selected hydrazines

Eleanor G Rogan, Betty A. Walker, Ralph Gingell, Donald L. Nagel, Bela Toth

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Selected hydrazines and related compounds were examined for their mutagenic activity in S. typhimurium strains TA1535 and TA1537. These in vitro assays were conducted with and without metabolic activation by Aroclor-induced rat-liver enzymes. Relatively high levels of mutagenicity were observed with phenylhydrazine · HCl, methylhydrazine, N′-acetyl-4-(hydroxymethyl)phenylhydrazine, and 4-(hydroxymethyl)benzenediazonium tetrafluoroborate, the stabilized salt of a carcinogenic metabolite of agaritine; only low levels of mutagenicity were observed with other compounds, although most are strong carcinogens. Several of the compounds were highly toxic to the bacteria, and detection of mutagenicity was enhanced by calculating the increase in mutagenic activity on the basis of the surviving fractions of bacteria.

Original languageEnglish (US)
Pages (from-to)413-424
Number of pages12
JournalMutation Research/Genetic Toxicology
Volume102
Issue number4
DOIs
StatePublished - Dec 1982

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Hydrazines
Bacteria
Monomethylhydrazine
Aroclors
Poisons
Metabolites
Carcinogens
Liver
Rats
Assays
Salts
Chemical activation
Enzymes
phenylhydrazine

ASJC Scopus subject areas

  • Toxicology
  • Genetics

Cite this

Microbial mutagenicity of selected hydrazines. / Rogan, Eleanor G; Walker, Betty A.; Gingell, Ralph; Nagel, Donald L.; Toth, Bela.

In: Mutation Research/Genetic Toxicology, Vol. 102, No. 4, 12.1982, p. 413-424.

Research output: Contribution to journalArticle

Rogan, Eleanor G ; Walker, Betty A. ; Gingell, Ralph ; Nagel, Donald L. ; Toth, Bela. / Microbial mutagenicity of selected hydrazines. In: Mutation Research/Genetic Toxicology. 1982 ; Vol. 102, No. 4. pp. 413-424.
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