Micro and nanotechnologies for bone regeneration: Recent advances and emerging designs

Marzieh Mohammadi, Seyed Ali Mousavi Shaegh, Mona Alibolandi, Mohammad Hossein Ebrahimzadeh, Ali Tamayol, Mahmoud Reza Jaafari, Mohammad Ramezani

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Treatment of critical-size bone defects is a major medical challenge since neither the bone tissue can regenerate nor current regenerative approaches are effective. Emerging progresses in the field of nanotechnology have resulted in the development of new materials, scaffolds and drug delivery strategies to improve or restore the damaged tissues. The current article reviews promising nanomaterials and emerging micro/nano fabrication techniques for targeted delivery of biomolecules for bone tissue regeneration. In addition, recent advances in fabrication of bone graft substitutes with similar properties to normal tissue along with a brief summary of current commercialized bone grafts have been discussed.

Original languageEnglish (US)
Pages (from-to)35-55
Number of pages21
JournalJournal of Controlled Release
Volume274
DOIs
StatePublished - Mar 28 2018

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Keywords

  • Biomaterials
  • Bone graft substitute
  • Fabrication techniques
  • Nanocarriers
  • Scaffolds
  • Tissue engineering

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Mohammadi, M., Mousavi Shaegh, S. A., Alibolandi, M., Ebrahimzadeh, M. H., Tamayol, A., Jaafari, M. R., & Ramezani, M. (2018). Micro and nanotechnologies for bone regeneration: Recent advances and emerging designs. Journal of Controlled Release, 274, 35-55. https://doi.org/10.1016/j.jconrel.2018.01.032