Metronidazole-induced acute pancreatitis

W. A. Corey, B. N. Doebbeling, K. J. DeJong, B. E. Britigan

Research output: Contribution to journalComment/debate

30 Citations (Scopus)

Abstract

Three cases of metronidazole-induced acute pancreatitis have been reported recently in three women who were being treated for nonspecific vaginitis. We report the fourth such case in a 63-year-old woman with long-standing Crohn's disease who developed acute pancreatitis that was temporally associated with the initiation of metronidazole therapy for a rectovaginal fistula. No other risk factors for pancreatitis were identified except for possibly Crohn's disease itself. We review the literature with regard to metronidazole-induced acute pancreatitis and suggest a possible mechanism. Metronidazole should be considered as a possible cause of acute pancreatitis, and its use should be discontinued if no other risk factor is found.

Original languageEnglish (US)
Pages (from-to)1213-1215
Number of pages3
JournalReviews of Infectious Diseases
Volume13
Issue number6
StatePublished - Jan 1 1991

Fingerprint

Metronidazole
Pancreatitis
Crohn Disease
Rectovaginal Fistula
Bacterial Vaginosis

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Corey, W. A., Doebbeling, B. N., DeJong, K. J., & Britigan, B. E. (1991). Metronidazole-induced acute pancreatitis. Reviews of Infectious Diseases, 13(6), 1213-1215.

Metronidazole-induced acute pancreatitis. / Corey, W. A.; Doebbeling, B. N.; DeJong, K. J.; Britigan, B. E.

In: Reviews of Infectious Diseases, Vol. 13, No. 6, 01.01.1991, p. 1213-1215.

Research output: Contribution to journalComment/debate

Corey, WA, Doebbeling, BN, DeJong, KJ & Britigan, BE 1991, 'Metronidazole-induced acute pancreatitis', Reviews of Infectious Diseases, vol. 13, no. 6, pp. 1213-1215.
Corey WA, Doebbeling BN, DeJong KJ, Britigan BE. Metronidazole-induced acute pancreatitis. Reviews of Infectious Diseases. 1991 Jan 1;13(6):1213-1215.
Corey, W. A. ; Doebbeling, B. N. ; DeJong, K. J. ; Britigan, B. E. / Metronidazole-induced acute pancreatitis. In: Reviews of Infectious Diseases. 1991 ; Vol. 13, No. 6. pp. 1213-1215.
@article{20c3873abb0b4adfa46d4beb6e472502,
title = "Metronidazole-induced acute pancreatitis",
abstract = "Three cases of metronidazole-induced acute pancreatitis have been reported recently in three women who were being treated for nonspecific vaginitis. We report the fourth such case in a 63-year-old woman with long-standing Crohn's disease who developed acute pancreatitis that was temporally associated with the initiation of metronidazole therapy for a rectovaginal fistula. No other risk factors for pancreatitis were identified except for possibly Crohn's disease itself. We review the literature with regard to metronidazole-induced acute pancreatitis and suggest a possible mechanism. Metronidazole should be considered as a possible cause of acute pancreatitis, and its use should be discontinued if no other risk factor is found.",
author = "Corey, {W. A.} and Doebbeling, {B. N.} and DeJong, {K. J.} and Britigan, {B. E.}",
year = "1991",
month = "1",
day = "1",
language = "English (US)",
volume = "13",
pages = "1213--1215",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Metronidazole-induced acute pancreatitis

AU - Corey, W. A.

AU - Doebbeling, B. N.

AU - DeJong, K. J.

AU - Britigan, B. E.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - Three cases of metronidazole-induced acute pancreatitis have been reported recently in three women who were being treated for nonspecific vaginitis. We report the fourth such case in a 63-year-old woman with long-standing Crohn's disease who developed acute pancreatitis that was temporally associated with the initiation of metronidazole therapy for a rectovaginal fistula. No other risk factors for pancreatitis were identified except for possibly Crohn's disease itself. We review the literature with regard to metronidazole-induced acute pancreatitis and suggest a possible mechanism. Metronidazole should be considered as a possible cause of acute pancreatitis, and its use should be discontinued if no other risk factor is found.

AB - Three cases of metronidazole-induced acute pancreatitis have been reported recently in three women who were being treated for nonspecific vaginitis. We report the fourth such case in a 63-year-old woman with long-standing Crohn's disease who developed acute pancreatitis that was temporally associated with the initiation of metronidazole therapy for a rectovaginal fistula. No other risk factors for pancreatitis were identified except for possibly Crohn's disease itself. We review the literature with regard to metronidazole-induced acute pancreatitis and suggest a possible mechanism. Metronidazole should be considered as a possible cause of acute pancreatitis, and its use should be discontinued if no other risk factor is found.

UR - http://www.scopus.com/inward/record.url?scp=0025837301&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025837301&partnerID=8YFLogxK

M3 - Comment/debate

C2 - 1775854

AN - SCOPUS:0025837301

VL - 13

SP - 1213

EP - 1215

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 6

ER -