Methamphetamine increases brain viral load and activates natural killer cells in simian immunodeficiency virus-infected monkeys

Maria Cecilia Garibaldi Marcondes, Claudia Flynn, Debbie D. Watry, Michelle Zandonatti, Howard S Fox

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Methamphetamine (Meth) abuse increases risky behaviors that contribute to the spread of HIV infection. In addition, because HIV and Meth independently affect physiological systems including the central nervous system, HIV-induced disease may be more severe in drug users. We investigated changes in blood and brain viral load as well as differences in immune cells in chronically simian immunodeficiency virus-infected rhesus macaques that were either administered Meth or used as controls. Although Meth administration did not alter levels of virus in the plasma, viral load in the brain was significantly increased in Meth-treated animals compared with control animals. Meth treatment also resulted in an activation of natural killer cells. Given the prevalence of Meth use in HIV-infected and HIV at-risk populations, these findings reveal the likely untoward effects of Meth abuse in such individuals.

Original languageEnglish (US)
Pages (from-to)355-361
Number of pages7
JournalAmerican Journal of Pathology
Volume177
Issue number1
DOIs
StatePublished - Jul 2010

Fingerprint

Simian Immunodeficiency Virus
Methamphetamine
Viral Load
Natural Killer Cells
Haplorhini
Brain
HIV
Drug Users
Macaca mulatta
HIV Infections
Central Nervous System
Viruses

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Methamphetamine increases brain viral load and activates natural killer cells in simian immunodeficiency virus-infected monkeys. / Marcondes, Maria Cecilia Garibaldi; Flynn, Claudia; Watry, Debbie D.; Zandonatti, Michelle; Fox, Howard S.

In: American Journal of Pathology, Vol. 177, No. 1, 07.2010, p. 355-361.

Research output: Contribution to journalArticle

Marcondes, Maria Cecilia Garibaldi ; Flynn, Claudia ; Watry, Debbie D. ; Zandonatti, Michelle ; Fox, Howard S. / Methamphetamine increases brain viral load and activates natural killer cells in simian immunodeficiency virus-infected monkeys. In: American Journal of Pathology. 2010 ; Vol. 177, No. 1. pp. 355-361.
@article{bdb5931ef32c40f2b46dba4624037405,
title = "Methamphetamine increases brain viral load and activates natural killer cells in simian immunodeficiency virus-infected monkeys",
abstract = "Methamphetamine (Meth) abuse increases risky behaviors that contribute to the spread of HIV infection. In addition, because HIV and Meth independently affect physiological systems including the central nervous system, HIV-induced disease may be more severe in drug users. We investigated changes in blood and brain viral load as well as differences in immune cells in chronically simian immunodeficiency virus-infected rhesus macaques that were either administered Meth or used as controls. Although Meth administration did not alter levels of virus in the plasma, viral load in the brain was significantly increased in Meth-treated animals compared with control animals. Meth treatment also resulted in an activation of natural killer cells. Given the prevalence of Meth use in HIV-infected and HIV at-risk populations, these findings reveal the likely untoward effects of Meth abuse in such individuals.",
author = "Marcondes, {Maria Cecilia Garibaldi} and Claudia Flynn and Watry, {Debbie D.} and Michelle Zandonatti and Fox, {Howard S}",
year = "2010",
month = "7",
doi = "10.2353/ajpath.2010.090953",
language = "English (US)",
volume = "177",
pages = "355--361",
journal = "American Journal of Pathology",
issn = "0002-9440",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Methamphetamine increases brain viral load and activates natural killer cells in simian immunodeficiency virus-infected monkeys

AU - Marcondes, Maria Cecilia Garibaldi

AU - Flynn, Claudia

AU - Watry, Debbie D.

AU - Zandonatti, Michelle

AU - Fox, Howard S

PY - 2010/7

Y1 - 2010/7

N2 - Methamphetamine (Meth) abuse increases risky behaviors that contribute to the spread of HIV infection. In addition, because HIV and Meth independently affect physiological systems including the central nervous system, HIV-induced disease may be more severe in drug users. We investigated changes in blood and brain viral load as well as differences in immune cells in chronically simian immunodeficiency virus-infected rhesus macaques that were either administered Meth or used as controls. Although Meth administration did not alter levels of virus in the plasma, viral load in the brain was significantly increased in Meth-treated animals compared with control animals. Meth treatment also resulted in an activation of natural killer cells. Given the prevalence of Meth use in HIV-infected and HIV at-risk populations, these findings reveal the likely untoward effects of Meth abuse in such individuals.

AB - Methamphetamine (Meth) abuse increases risky behaviors that contribute to the spread of HIV infection. In addition, because HIV and Meth independently affect physiological systems including the central nervous system, HIV-induced disease may be more severe in drug users. We investigated changes in blood and brain viral load as well as differences in immune cells in chronically simian immunodeficiency virus-infected rhesus macaques that were either administered Meth or used as controls. Although Meth administration did not alter levels of virus in the plasma, viral load in the brain was significantly increased in Meth-treated animals compared with control animals. Meth treatment also resulted in an activation of natural killer cells. Given the prevalence of Meth use in HIV-infected and HIV at-risk populations, these findings reveal the likely untoward effects of Meth abuse in such individuals.

UR - http://www.scopus.com/inward/record.url?scp=77954577011&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954577011&partnerID=8YFLogxK

U2 - 10.2353/ajpath.2010.090953

DO - 10.2353/ajpath.2010.090953

M3 - Article

C2 - 20489154

AN - SCOPUS:77954577011

VL - 177

SP - 355

EP - 361

JO - American Journal of Pathology

JF - American Journal of Pathology

SN - 0002-9440

IS - 1

ER -