Methamphetamine abuse, HIV infection, and neurotoxicity

Benjamin C. Reiner, James P. Keblesh, Huangui Xiong

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

Methamphetamine (Meth) use and human immunodeficiency virus (HIV) infection are major public health problems in the world today. Ample evidence indicates that HIV transfection risk is greatly enhanced with Meth use. Studies have shown that both HIV infection and Meth abuse can cause neuronal injury leading to neurodegeneration. While many studies have focused on the individual effects of Meth and HIV on the brain, few investigations have been carried out on their co-morbid effect in the nervous system. In this review, we try to summarize recent progress on individual effects of Meth and HIV on neurodegeneration and their potential underlying mechanisms, in addition to exploring their co-morbid effect on the brain.

Original languageEnglish (US)
Pages (from-to)162-179
Number of pages18
JournalInternational Journal of Physiology, Pathophysiology and Pharmacology
Volume1
Issue number2
StatePublished - Dec 1 2009

Fingerprint

Methamphetamine
Virus Diseases
HIV
Brain
Nervous System
Transfection
Public Health
Wounds and Injuries

Keywords

  • AIDS
  • HIV-1
  • Methamphetamine
  • Neurodegeneration
  • Neurotoxicity

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Physiology
  • Physiology (medical)

Cite this

Methamphetamine abuse, HIV infection, and neurotoxicity. / Reiner, Benjamin C.; Keblesh, James P.; Xiong, Huangui.

In: International Journal of Physiology, Pathophysiology and Pharmacology, Vol. 1, No. 2, 01.12.2009, p. 162-179.

Research output: Contribution to journalReview article

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